sarcoma & MM (treatment site)

STS occur where?

extraskeletal CT

extraskeletal CT provide what 3 things?

connection, support, and movement

common cells in the CT are what 3 things?

mesoderm

primitive mesenchyme

ectoderm

STS arise in structures that have CT like what

blood vessel walls, pleura, pericardium, endothelium of blood vessels, bone, cartilage, muscles, and soft CT

STS mostly occur where in adults?

extremities (lower)

STS mostly occur where in children?

trunk

H&Ncom

common symptoms of STS is what?

painless mass

when irradiating sarcomas, it is important that the entire circumference of the extremity or area is not within the tx field, why?

a strip must be left so that lymph can be drained and to avoid edema

(T/F) lymphatic spread is rare

T

(T/F) there are 50 subtypes such as leiomyosarcoma (smooth muscle), liposarcoma (fat), synovial sarcoma, malignant peripheral nerve sheath tumors, malignant fibrous histiocytomas (mixed fibroblasts and other cells)

T

most common pathology in adult is what

malignant fibrous histiocytomas (MFH)

most common pathology in children nis what?

rhabdomyosarcoma

highly malignant tumors in the skeletal muscles that can occur in any location of the body

rhabdomyosarcoma

rhabdomyosarcoma subtypes include what 5 subtypes? which is the most common?

embryonal (most common)

alveolar

pleomorphic/anaplastic

mixed type

spindle cell

most common site of rhabdomyosarcoma is the what

genitourinary tract

what is the most common bone tumor?

osteosarcoma

osteosarcoma occurs where?

osteoblasts (immature bone) in the osteoid tissue

where does osteosarcoma most frequently occur?

metaphysis of extremities like the distal femur, proximal tibia, or shoulder

is osteosarcoma radio resistance or radiosensitive?

radioresistance

(T/F) osteosarcoma grows quickly and distant spread occurs quickly

T

rhabdomyosarcoma- typically occur btw the ages of ?-?

osteosarcoma- typically occurs btw the ages of ?-?

0-19

10-19

what is the second most common bone tumor?

ewings sarcoma

ewings occurs most frequently where?

diaphysis of the femur

what has an onion-shaped appearance on an xray

ewing

ewing is more common in children and teens younger than the age of what?

19

bone tumors of the cartilage is called what?

chondrosarcomas

chondrosarcomas most occurs where (3)

pelvis

upper leg

shoulder

chondrosarcomas is more common in adults over the age of what?

40

(T/F) spread patterns aggressively spread to local areas

T

most common site of distant spread?

lung

(T/F) less common sites of distant spread are the bones, liver, and skin

T

multiple myeloma is the malignancy of what?

plasma cells

MM is the irregular absorption of bone that leads to multiple painful bony lesions

T

MM occurs in what cells of the bone marrow?

B cell lymphocytes

(T/F) patient can be dx w MM when 10% of bone marrow cells are plasma cells upon aspiration

T

MM is usually treated w what?

RT

chemo