Diabetes Management Jeopardy Questions

Invokamet

brand for Metformin and Canagliflozin

Glipizide (Glucotrol)

This sulfonylurea has no active metabolites

Linagliptin (Tradjenta)

This DPP-4 inhibitor requires no renal dose adjustment

GLP-1 agonists

Avoid this drug class in patients with gastroparesis

Thiazolidinediones

Contact your provider if you experience trouble breathing, swelling, and rapid weight gain after using a medication from this class

glucose-independent

Sulfonylureas display ______-_____ insulin secretion

administer with largest meal in evening OR switch to ER formulation

What to do for patients experiencing GI SEs from Metformin

vitamin B12

Deficiency of this vitamin may occur secondary to chronic Metformin use

similar mechanism of action without added benefit

Don't use DPP-4 inhibitors and GLP-1 agonists together for this reason

Rybelsus (Semaglutide)

the only oral GLP-1 agonist medication

beta-adrenergic antagonists (beta-blockers)

this class of medications can mask the signs of hypoglycemia when given with sulfonylureas

Saxagliptin (Onglyza)

this DPP-4 inhibitor can increase the risk of heart failure

upper belly pain

vomiting

belly tenderness

fever

tachycardia

Patients might report these symptoms of pancreatitis when using Mounjaro

Dapagliflozin (Farxiga)

Empagliflozin (Jardiance)

these 2 medications can be prescribed in patients with CHF or CKD without a history of DM

Gemfibrozil (Lopid)

Actos therapy should not exceed 15 mg when administered with this strong CYP2C8 inhibitor

Inpefa (Sotagliflozin)

this oral medication is the first and only SGLT-1 and SGLT-2 inhibitor

SGLT-2 inhibitors

Administration of this drug class in the morning is recommended to avoid nocturia

delayed gastric emptying = delayed OC absorption = decreased oral contraceptive levels.

counsel to take 1 hour before GLP-1RA and add a barrier contraceptive 4 weeks after initiation or dose increase

SS, a 33-year-old female, picks up a new prescription for Bydureon at your pharmacy. You notice her medication list also includes Loestrin. Explain the drug-drug interaction. How should you counsel her?

warfarin, lithium, digoxin

GLP-1RA can increase drug levels of these NTI meds

Pioglitazone

This medication can reduce the risk of ASCVD/MACE; however, it may increase the risk of heart failure

Fournier's gangrene

This rare, life-threatening bacterial infection of the genitals and perineum can be caused by SGLT-2 inhibitors

glucose tablets and glucose gels

Hypoglycemia caused by acarbose must be treated with these two specific agents

insulin and secretagogues

reduce the dose of these classes of medications when given with GLP-1RAs

Saxenda (Liraglutide)

Wegovy (Semaglutide)

Zepbound (Tirzepatide)

List the brand name and generic for GLP-1 RA agents indicated for treatment of obesity

Liraglutide

Don't recommend this GLP-1 agonist in patients desiring weekly injections

Trulicity

This brand name agent is approved for primary and secondary ASCVD prophylaxis.

Meglitinides

This class of medication should be taken orally TID 15-30 minutes prior to each meal

Ozempic

this medication utilizes the following titration schedule

Sulfonylureas and Meglitinides

Duplicate therapy of these secretagogues may cause severe hypoglycemia