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Water, Methanol, Ethanol, Ammonia, Acetic Acid
Protic solvents
Acetone, DMSO, DMF, Acetonitrile, HMPA
Aprotic solvents
What kind of solvent is best for SN1 and E1 reactions?
Protic solvents
What kind of solvent is best for SN2 and E2 reactions?
Polar aprotic solvents
What are some examples of strong bases, but weak nucleophiles. These promote E2 mechanisms
NaH, DBN, and DBU
What are some examples of strong bases and nucleophiles. These promote SN2 and E2 mechanisms
HO-, MeO-, EtO-
What are some examples of weak bases, but strong nucleophiles. These promote SN1 and SN2 mechanisms
I-, Br-, Cl-, RS-. HS-, RSH, H2S
EtOH
Weak base and weak nucleophile
H2O
Weak base and weak nucleophile
MeOH
Weak base and weak nucleophile