Unit 8 Homologous Recombination

A set of vocabulary flashcards detailing key concepts related to homologous recombination in both prokaryotes and eukaryotes.

Homologous Recombination

A process essential in bacteria and eukaryotic mitosis to repair DNA damage and stalled replication forks, and in eukaryotic meiosis for generating diversity and chromosome segregation.

DbSB (Double Stranded Break)

A break in both strands of DNA that can be spontaneous or induced, initiating homologous recombination.

Strand Invasion

The process where a 3' overhang invades another duplex of DNA during homologous recombination.

RecA protein

A key component in homologous recombination in E. coli, facilitating the pairing of single-stranded DNA with double-stranded DNA.

Holliday junction

An intermediate structure during homologous recombination where two homologous helices are connected by the exchange of two of the four strands.

Meiotic Recombination

A type of homologous recombination that begins with a double-stranded break induced by the Spo11 protein complex and involves the exchange of genetic material between homologous chromosomes.

Gene Conversion

A process during homologous recombination where one allele is converted into another, leading to genetic variation.

Crossover Products

Results of homologous recombination where crossover events occur, resulting in genetically distinct chromosomes.

Mismatch repair enzymes

Enzymes that repair mismatches in DNA sequences, which can occur during strand invasion in gene conversion.