Coagulation Disorder N335

what is thrombocytopenia

low platelets, a problem after its under 100,000

what is the cause of immune thrombocytopenic purpura (ITP)

acquired autoimmune syndrome that destroys circulating plts

•Normal platelets survive 8-10 days with ITP platelets survive 1-3 days

•Autoimmune issue

TTP Thrombotic Thrombocytopenia Purpura

• autoimmune

•Abnormal platelet aggregation leading to inappropriate clotting

•Autoimmune issue

Heparin Induced Thrombocytopenia (HIT)

•Complication-venous & arterial thrombosis

•From heparine

what percent of pts on Heparin develop HIT

8-17%

clinical manifestations of thrombocytopenia

•Bleeding -mucosal bleeding

•Ex. Epistaxis, gingival

•Skin- purpura, petechiae, ecchymosis

•Prolonged bleeding after procedures: IM, IV

major complication of thrombocytopenia and where does it typically happen

hemorrhage

•Brain-may be fatal

•Retinal

•Joints

•Hypovolemia- tachycardia, hypotensive

at what level of platelets do you question what is going on

150,000

what level of platelets can you expect prolonged bleeding

less than 50,000

when can spontaneous, life threatening bleeding occur

less than 20,000

when should you do a platelet transfusion

less than 10,000

what is hemophilia

X linked recessive genetic disorder resulting in deficiency of coagulation factors 

what is a result of hemophilia

prolonged breathing

hemophilia A

Factor VIII

80% of hemophilia

Hemophilia B

factor IX

Von Willenbrand’s disease

Factor VIII and platelet dysfunction (most common bleeding disorder that affects both males & females)