Pyruvate dehydrogenase

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9 Terms

1
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Outline the link reaction (3 steps)

pyruvate is trasnsported across the inter membrane matrix and decarboxylated by pyruvate dehydrogenase to form acetylcoenzyme A, yeilding NADH

2
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List the 3 different enzymes that make up pyruvate dehydrogenase

  • pyruvate dehydrogenase component

  • dihydrolipoly transacetylase

  • dihydrolipoly dehydrogenase

3
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State the prosthetic group of pyruvate dehydrogenase component

TTP

4
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State the prosthetic group of dihydrolipoly transacetylase

lipoamide

5
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State the prosthetic group of dihydrolipoly dehydrogenase

FAD

6
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What reaction does pyruvate dehydrogenase component catalyse?

oxoxidative decarbolyxation of pyruvate

7
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What reaction does dihydrolipoly transacetylase catalyse?

transfer of acetyl group to co-enzyme A

8
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What reaction does dihydrolipoly dehydrogenase catalyse?

regeneration of the oxidised form of lipoamide

9
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<p>Describe action of acetylcoenzyme</p>

Describe action of acetylcoenzyme

  1. TTP takes electron from pyruvate, both decarboxylating and binding it

  2. complex binds with lilipoic acid, having it move up from transacetylase to the pyruvate dehydrogenase

  3. sulfur from lilipoic acid is used to form a thioester bridge, binding the acetyl group to the lilipoic acid, leaving one sulfur reduced

  • the transacytlase lilipoic acid domain moves out of pyruvate dehydrogenase

  1. acetyl group is transferred to CoA

  2. lilipoic acid moves to dihydrolipoyl dehydrogenase domain in order to be reoxidised, forming FADH2

  3. FADH2 passes electrons to to NAD = NADH + H

<ol><li><p><span style="color: yellow">TTP </span>takes electron from pyruvate, both decarboxylating and binding it</p></li><li><p>complex binds with <span style="color: #f018b1">lilipoic acid</span>, having it move up from <span style="color: #ff00db">transacetylase </span>to the <span style="color: yellow">pyruvate dehydrogenase</span></p></li><li><p>sulfur from <span style="color: #ff00d5">lilipoic acid</span> is used to form a thioester bridge, binding the acetyl group to the<span style="color: #ff00c2"> lilipoic acid</span>, leaving one sulfur reduced</p></li></ol><ul><li><p>the transacytlase lilipoic acid domain moves out of <span style="color: yellow">pyruvate dehydrogenase</span></p></li></ul><p></p><ol start="4"><li><p><span style="color: #93f0ff">acetyl </span>group is transferred to CoA</p></li><li><p><span style="color: #ff00db">lilipoic acid</span> moves to <span style="color: #23ff87">dihydrolipoyl dehydrogenase</span> domain in order to be reoxidised, forming FADH2</p></li><li><p>FADH2 passes electrons to to NAD = NADH + H</p></li></ol><p></p>