In 1848, railroad worker Gage had a railroad spike shoot through his skull and take out part of his frontal lobe (specifically the prefrontal cortex).
He had trouble holding a job afterwards and his friends said that "Gage was no longer Gage." He had lost his social inhibitions, he was vulgar, rude, impatient, and inconsiderate.
His lost part of his prefrontal cortex, where decisions and planning for the future take place