SSTI: Drug Dosing

What is the dose of dicloxacillin for MSSA?

500 mg PO QID

Does dicloxacillin need to be renally adjusted?

no

What is the dose of cephalexin for MSSA?

500 mg PO QID

Does cephalexin have to be renally adjusted?

yes

What is the dose of clindamycin for MSSA?

300 mg PO TID

Does clindamycin have to be renally adjusted?

no

What is the dose of ampicillin/sulbactam for MSSA?

1.5-3 g IV q6h

Does ampicillin/sulbactam need to be renally adjusted?

yes

What is the dose of nafcillin/oxacillin for MSSA?

1-2 g IV q4-6h

Does nafcillin/oxacillin need to be renally adjusted?

no

What is the dose of cefazolin for MSSA?

1-2 g IV q8h

Does cefazolin need to be renally adjusted?

yes

What is the IV dose of clindamycin for MSSA?

600 mg IV q8h

What is the dose of TMP/SMX (Bactrim) for MRSA?

1 TAB (160/800) PO BID

Does Bactrim need to be renally adjusted?

yes

What is the dose of doxycycline for MRSA?

100 mg PO BID

Does doxycycline need to be renally adjusted?

no

What is the dose of linezolid for MRSA?

600 mg PO q12h

Does linezolid need to be renally adjusted?

no

What is the usual dosing of Vancomycin for severe SSTIs?

15 mg/kg q12h rounded to the nearest 250 mg increment

Does vancomycin need to be renally adjusted?

yes

What is the ideal trough range for vancomycin for SSTIs?

10-15 mcg/mL

What is the dose of daptomycin for MRSA?

4 mg/kg IV daily

Does daptomycin have to be renally adjusted?

yes

What is the dose of ceftaroline for MRSA?

600 mg IV q12h

Does ceftaroline have to be renally adjusted?

yes

What is the dose of dalbavancin/oritavancin for MRSA?

D: 1000 mg; O: 1200 mg IV x1

Does dalbavancin/oritavancin have to be renally adjusted?

no