[PCOG-LEC-SEMIS-02-PT7] ALKALOIDS

THIS FLASHCARDS IS ABOUT [PCOG] ALKALOIDS - TROPANE: QUINOLINE

Tryptophan

What is the precursor of quinoline?

Supplemental Info

This is the structure for quinoline-containing drugs.

Quinoline

What is the basic nucleus of alkaloids?

Cinchona

Quinoline is obtained from?

• Cinchonine

• Cinchonidine

What are the (2) Parent Alkaloids of Quinoline?

Hint: CIN-NINE-DINE

• Quinine

• Quinidine

From the parent alkaloids, cinchonine and cinchonidine, these two (2) can be formed.

Hint: QUI-NINE-DINE

Cinchonine

What is the main parent alkaloid?

• Cinchona

• Cuprea

What are the (2) Plants of Quinoline?

Hint: CIN-CUP

Cinchona

This quinoline is from the dried bark or stem or of the root of Cinchona succirubra or Cinchona calisaya (Rubiaceae).

• Cinchona succirubra

• Cinchona calisaya

What are the (2) scientific names of Cinchona?

• Peruvian Bark

• Countess

• Jesuits Bark

What are the other (3) names of Cinchona?

Hint: PCJ

Red Cinchona

Cinchona succirubra is the?

Cinchona succirubra

Red Cinchona is the?

Yellow Cinchona

Cinchona calisaya is the?

Cinchona calisaya

Yellow Cinchona is the?

Thalleioquin Test

What is the test used for Quinine?

Hint: TT

(+) Fine blue fluorescence turns to green precipitate

What is the positive result of Thalleioquin Test for Quinine?

1. Anti-malarial

2. Quinidine

3. Antiarrhythmic

4. Skeletal muscle relaxant

5. Nocturnal Recumbency

Quinine and Quinidine are both (1)__________ but (2)_____ is weaker; is used as (3)_____ instead. Quinine is also used as a (4)____________ relaxant; used as treatment for (5)____________________ or leg cramps.

Nocturnal Recumbency

Leg Cramps is also known as?

1. Indian

2. Jesuits

3. Canizares

4. Countess Ana de Osorio

5. Count of Chinchon of Peru

History of Cinchona:

• Discovered by (1)_____ (a sick man drank water from a pond with cinchona trees)

• (2)_____ learned and taught others; (3)_____ (a Spanish official)

• Sent to Juan de Vega who was curing (4) Countess _________________; wife of (5) Count of ________________

Cinchonism

What is the term for cinchona toxicity?

1. Loss of hearing

2. Impaired sight

3. Ringing in the ears

Toxicity of Cinchona:

• Temporary (1) loss of ________

• (2) Impaired _____

• (3)_____ in the ears

Tinnitus

Ringing in the ears is also known as?

Cuprea

This quinoline is from Remijia purdieana and Remijia pedunculata (Rubiaceae).

• Remijia purdieana

• Remijia pedunculata

What are the (2) scientific names of Cuprea?

Cuprea Bark

Cuprea is also known as?

Quinidine

Cuprea is a commercial source of?

Hint: Antiarrhythmic

Cuprea

This is a commercial source of quinidine.