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making glucose
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What is the rate-limiting enzyme of gluconeogenesis?
Fructose-1,6-bisphosphatase
What reaction does it catalyze?
Fructose-1,6-bisphosphate → Fructose-6-P
What activates fructose-1,6-bisphosphatase?
ATP, citrate
What inhibits fructose-1,6-bisphosphatase?
AMP, Fructose-2,6-bisphosphate
Low energy → gluconeogenesis is…
OFF
What molecule controls both glycolysis and gluconeogenesis?
Fructose-2,6-bisphosphate
Insulin favors which pathways?
Glycolysis + Glycogenesis
Glucagon favors which pathway?
Gluconeogenesis