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What are the two main components of the circulatory system ?
Cardiovascular system (heart, blood,vessels), lymphatic system ( carries lymph)
What is the volume of blood in adult males and females?
Mouse 5-6 liters
Females 4-5liters
What is the functions of erythrocytes
Transports oxygen and carbon dioxide
Where are blood cells formed
In red bone marrow
What is erythropoietin and its function
A hormone from kidneys, that stimulates red blood cell production
What happens to old red blood cells
Phagocytosed in liver/ spleen iron is recycled and stored as ferritin
What is hemochromatosis
A disorder where too much iron is absorbed leading organ damaged
what is hemophilia?
Impaired blood clotting treated with clotting factor infusions
What is polycythemia
Excess RBCs, making blood thick and slow flowing
What is leukemia
Cancer from uncontrolled WBC production in bone marrow
What is thalassemia
A disorder with insufficient hemoglobin chain production; RBCs rupture easily
What stem cells give rise to blood cells ?
Blood stem cells become myeloid and lymphoid stem cells
What are platelets and their role
Fragment of megakaryocytes help in blood clotting
What are the types of leukocytes?
Neutrophils, eosinophils, basophils, monocytes, B & T lymphocytes
What are leukocytes and their function
White blood cells; fight infections have nuclei, and can exit blood vessels
What are the components of blood
Cellular elements (RBCs, WBCs, plateletd) and plasma
What is hematrocrit and its normal range
Percentage of blood volume that is RBcs
What is the shape and lifespan of erythrocytes
Biconcave discs, no nuclei / organelles 100-120 days of lifespan.
What are the functions of blood
Transports nutrients, oxygen, waste, and hormones; carries WBCs, regulates temperature