TCA CYCLE (Study Guide + Answers)

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12 Terms

1
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What are the PDH cofactors?

TPP, Lipoate, FAD, NAD⁺, CoA

2
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PDH reaction products

Acetyl-CoA + NADH + CO₂

3
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What enzyme performs substrate-level phosphorylation in TCA?

Succinyl-CoA synthetase (makes GTP)

4
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What is the rate-limiting step of TCA?

Citrate synthase

5
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What is the product of isocitrate dehydrogenase?

α-Ketoglutarate

6
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Irreversible TCA steps

Citrate synthase, Isocitrate DH, α-KG DH

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What does succinate DH produce?

FADH₂

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What does malate DH produce?

NADH

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What high-energy bond drives GTP formation?

Thioester bond

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How many CO₂ per TCA turn?

2

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Where does the TCA cycle occur?

Mitochondrial matrix

12
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Which enzyme is NOT anaplerotic?

Pyruvate carboxykinase