Pharmacology in oncology and immunology

chemotherapy by definition

anything treated with a chemical

why does chemotherapy have effectiveness

works because cancer cell attributes contribute to their effectiveness

the side effects of chemotherapy depends on

depends on where we are treating it

describe the cell cycle

g1- DNA synthesis enzymes produced

S- DNA synthesis / replication

G2- RNA/ protein synthesis

M- mitosis

G0- resting

cell cycle non specific means

works anywhere

cell cycle specific means

works at only one or two sites in the cell cycle

if the cell has a high mitotic index,

the cell is growing bigger and faster

if the cell has a fast growth fraction-

the drug has a good chance at being more effective

if the doubling time of a cell is short,

the cell is growing really fast

true or false, large tumors have a fast doubling time

false, they have a slow doubling time

if they are in remission for a certain amount of time,

that is called a cure

the primary goal of chemotherapy is

to find a cure

staging tumors means

is it mestastisis

malignancy

the adverse effects of chemotherapy agents can be used by the term

BAG

bone marrow suppression

alopecia

gastrointenstinal signs

why can cardiovascaular agents cause vascular injury

this is due to their PH

what does pulse dosing mean

give them a big dose of a drug then a little later give another drug

why do we want the concentration of the drug to get to 0

so we dont have any problems

what cells are in a fetus

rapidly growing cells

if you get a chemo agent on you, how can you remove it

flush with large volumes of water

what color is the chemotherapy bags

yellow

why do we not use bleach to clean agents

because it can come in contact with and cause even more problems

if the client does not finish the chemo agents. what must they do

they must bring them back to the clinic where they got the agent from

the primary interferon that is used in chemotherapy

alpha

myelosuppression is

bone marrow suppressive

the primary granulocyte is

neutrophils

interlukins are used for

mass cells in k9 or feline FSA

monoclonal antibodies are used for

biologic responses

what is apoptosis

the cells will start to die

anti tumor vaccines target

melanoma

targets tyrosinase

immune mediated response is the response

that has a specific response that can lead to problems if they are overreacted

lupus is disease that

almost looks like cancer

describe cyclosporine

transplant so the body does not reject the transplant

tacrolimus shuts down the immune system due to

due to their immunosuppressant macrolide

why should azathioprine not be used in pregnant animals

can cause problems in the fetus

asparaganase is the enzyme that can stop the tumor from using

asparagine

tyrosine kinase inhibitor decreases

tumor blood supply

what does it mean if the alkylating agents are cross linking DNA

it means that they cannot replicate the DNA

carcinoma is from

epithelial cell origin but they are malignant

alkaloids are

plant deravitatives and work on the miotic phase of the cell cycle