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Abdominopelvic cavity
The continuous cavity formed by the abdomen and pelvis, containing organs such as the stomach, intestines, and liver.
Absolute refractory period
Prevents the backward travel of an action potential along an axon
absorption
Transfer of substances from the lumen of the kidney or gastrointestinal tract to the extracellular space (Ch 3, 5, 15, 21)
Absorption vs Secretion
Absorption is transport from the lumen to the extracellular fluid; secretion is from the extracellular fluid to the lumen.
acclimation
Physiological adjustment to environmental change in a laboratory setting (Ch 1)
acclimatization
The adaptation of physiological processes to a given set of environmental conditions (Ch 1)
Acetylcholine
A neurotransmitter that is rapidly broken down by acetylcholinesterase in the synaptic cleft.
acetylcholine (ACh)
Neurotransmitter used by neurons of the central and peripheral nervous system.
acetylcholinesterase (AChE)
Enzyme that breaks down acetylcholine in the synapse.
Acid
A substance that increases the hydrogen ion concentration in a solution.
Action Potential
A rapid rise and subsequent fall in voltage or membrane potential across a cellular membrane, primarily in neurons.
Activation energy
The energy required to initiate a reaction.
activation gate
Sodium channel gate that opens to initiate an action potential.
Active transport
Movement of molecules across cell membranes requiring energy input from an outside source, such as ATP.
Adaptive significance
The reason why a physiological response helps an organism survive in a particular environment.
addition reaction
Reaction in which a functional group is added to one or more of the substrates.
adherens junctions
Bands that link actin microfilaments in adjacent cells together with the help of cadherins (Ch 4)
adipocyte
Fat cells (Ch 3, 16, 22)
adrenal cortex
Outer portion of adrenal gland that produces steroid hormones (Ch 7, 11, 20, 23)
adrenal gland
Endocrine and neuroendocrine gland that sits on top of the kidney (Ch 7, 11, 18, 23)
adrenergic neuron
Neuron that secretes norepinephrine.
Adrenergic Neurons
Neurons that secrete norepinephrine.
adrenergic receptor
Receptor that binds to norepinephrine or epinephrine.
Adrenocorticotrophic hormone (ACTH)
Anterior pituitary hormone that targets the adrenal cortex to control the synthesis and release of cortisol.
aerobic
Adjective pertaining to a process that requires oxygen.
Affinity
The degree to which a substance tends to combine with another.
agonist
Molecules that combine with a receptor and mimic a response (Ch 2, 6, 7, 8, 11)
Agonists
Competing ligands that mimic each other's actions
allosteric modulator
Binds to an enzyme away from the binding site and change the shape of the active site (Ch 2)
alternative splicing
The processing of mRNA to make different proteins from a single strand of DNA.
amination
Addition of an amino group to a molecule.
Amine hormones
Hormones derived from either tyrosine or tryptophan that may behave like peptide hormones or a combination of steroid and peptide hormones.
Amino acid-derived (amine) hormones
Hormones created from modifications of single amino acids, such as tryptophan or tyrosine.
Amino acid-derived hormones
One of the three main chemical classes of hormones
AMPA and NMDA receptors
The receptor channels involved in long-term potentiation.
AMPA receptor
Glutamate receptor-channel that allows net Na+ influx.
AMPA receptors
Ligand-gated monovalent cation channels in the CNS.
amplifier enzyme
A membrane enzyme that creates two or more second messengers during signal transduction (Ch 6, 7)
Amplitude of graded potentials
Determined by the strength of the triggering event
anabolism
Metabolic pathways that require a net input of energy and that synthesize small molecules into larger ones.
anaerobic
Adjective pertaining to a process that does not require oxygen.
anchoring junction
Form of cell-cell or cell-matrix junctions (Ch 3)
Anion
What do you call a negatively charged ion?
Antagonism
The interaction where one hormone opposes the action of another hormone.
Antagonism (receptor effect)
A situation where one hormone decreases the number of receptors for the opposing hormone.
antagonist
One substance opposes the action of another (Ch 2, 6, 8, 11)
Antagonistic hormone
What is the term for a hormone that opposes the action of another hormone?
Antagonistic hormones to insulin
Glucagon and growth hormone.
anterior pituitary gland
An endocrine gland in the brain that secretes multiple hormones (Ch 7, 9, 23, 26)
Anterior pituitary hormones and their primary targets
1. Growth hormone (GH) - liver, 2. Thyroid-stimulating hormone (TSH) - thyroid, 3. Adrenocorticotropic hormone (ACTH) - adrenal cortex, 4. Prolactin (PRL) - mammary glands, 5. Follicle-stimulating hormone (FSH) - gonads, 6. Luteinizing hormone (LH) - gonads.
anticodon
The tRNA base triplet that pairs with the mRNA codon for an amino acid.
Antidiuretic hormone (ADH)
Another name for vasopressin.
antidiuretic hormone (ADH, vasopressin)
Posterior pituitary hormone that regulates water reabsorption in the kidney (Ch 7, 20)
Antiport carrier
A carrier protein that moves molecules in opposite directions.
Apical membrane
Also known as the mucosal membrane.
apical membrane/surface
The surface of transporting epithelial cells that faces the lumen of an organ (Ch 3, 5, 10, 19, 20, 25)
Apoptosis
Programmed cell death, a normal part of development and health maintenance.
Aquaporin (AQP)
The protein that creates special water channels in cell membranes.
Arachidonic Acid Cascade
A process that creates lipid signal molecules such as leukotrienes, prostaglandins, and thromboxanes.
aspartate
Amino acid that also acts as an excitatory neurotransmitter.
astrocyte
Glial cells in the CNS that contact both neurons and blood vessels.
Astrocytes
Maintaining homeostasis and forming part of the blood-brain barrier
atherosclerosis
Pathological condition in which lipids and calcium deposit beneath the vascular endothelium (Ch 5, 15)
ATP
The molecule primarily responsible for energy transfer and storage in cells.
ATP-gated K+ channel
Which type of channel in beta cells closes when ATP binds to it?
autocrine signal
A local chemical signal that acts on the cell that secreted it (Ch 6, 7, 8)
Autocrine Signals
Chemical signals that act on the same cell that secreted them.
Autonomic division control
Smooth and cardiac muscles, exocrine glands, some endocrine glands, and some types of adipose tissue.
Autonomic neurons
Neurons that control smooth and cardiac muscles, glands, and some adipose tissue.
Axon
A long process of a neuron that carries outgoing information
axonal transport
Movement of material between the axon terminal and the cell body.
axon hillock
Region of the axon where it joins the cell body. Often contains the trigger zone.
axon terminal
The distal end of a neuron where neurotransmitter is released into a synapse.
basal lamina
An acellular layer of extracellular matrix that lies beneath an epithelium, holding the epithelial cells to underlying cell layers. Synonym: basement membrane (Ch 3, 9, 13, 15, 19, 26)
Base
A substance that decreases the hydrogen ion concentration in a solution.
Basolateral membrane definition
The three surfaces of an epithelial cell that face the extracellular fluid, below the tight junctions.
basolateral membrane/surface
The sides of transporting epithelial cells that face the extracellular fluid.
Basolateral membrane transporter
Na+-K+-ATPase.
Berthold's experiment significance
It demonstrated that testes secrete something into the blood that affects the entire body, laying the foundation for the field of endocrinology
Beta blockers
Primarily used to treat high blood pressure.
binding site
Region of an enzyme or transport protein to which the substrate binds (Ch 2)
bioenergetics
The study of energy flow through biological systems.
Biological membranes formation
Noncovalent associations of phospholipids and proteins.
Biological transport
The movement of materials within and between compartments, requiring energy from concentration gradients or chemical bonds.
biomolecule
Organic molecules associated with living organisms (Ch 2)
blind study
An experiment in which the subject does not know if he or she is receiving the experimental treatment (Ch 1)
blood
The circulating portion of the extracellular fluid (Ch 3, 11, 16, 17, 18)
bone
Calcified connective tissue (Ch 3, 9, 10, 12, 15, 16, 23)
Branches of the autonomic division
Sympathetic and parasympathetic.
brown fat
Adipose cells that contain multiple lipid droplets (Ch 3, 23)
Buffer
A solution that resists changes in pH when an acid or base is added.
Bulk Flow
The movement of fluids within a compartment due to a pressure gradient, carrying all its component parts with it.
cadherin
Membrane-spanning protein of adhesive junctions that links two cells together (Ch 3)
calcium as an intracellular messenger
Activates protein kinases.
Calmodulin
A protein that binds calcium ions and alters enzyme or transporter activity or the gating of ion channels.
Cannon's four postulates of homeostatic control
The nervous system plays an important role in maintaining homeostasis.
Carbohydrates
Organic molecules associated with living organisms, including carbohydrates, lipids, proteins, and nucleotides.
Carrier Protein
A transport protein that binds with specific substrates and carries them across the membrane by changing conformation.
Carrier proteins
Carrier proteins protect steroid hormones from enzymatic degradation, extending their half-life.
Carrier proteins
Proteins that bind with specific substrates and change conformation to move them across the membrane.