Septic Shock

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14 Terms

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Define sepsis

Is a life-threatening organ dysfunction caused by a dysregulated host response to infection

2
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Define Septic Shock

Is a subset of sepsis with persistent hypotension and tissue hypo perfusion despite adequate fluid resuscitation.

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How is septic shock identified?

MAP <65 mmHg despite fluids

Serum lactate > 2mmol/L

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What are the main events for the pathophysiology for septic shock

  1. Infection enters the blood stream —> bacteria releases endotoxins

  2. Immune response is triggered:

  • cytokines released cause vasodilation

  • increase in capillary permeability which increases leakage of fluid from vessels

  1. The results in Hypotension (due to vasodilation, hypoperfusion( due to less oxygen in tissues) and Organ dysfunction (due to lack of oxygen and inflammation)

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What would the vital signs look like

Increased HR

Increased RR

Decreased BP

Normal or elevated Temp

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What is the treatment for septic shock

IV fluids and vasopressors

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