Anti-Thrombotic Medications

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25 Terms

1

Drugs can affect coagulation and haemostasis by acting on __________.

Platelet aggregation, the coagulation pathway, fibrinolysis
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2
Examples of antiplatelet agents include __________ and __________.
Aspirin and Clopidogrel
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3
The key role of aspirin as an antiplatelet agent is to __________ platelet aggregation.
inhibit
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4
Low Molecular Weight Heparins (LMWH) such as __________ are used for anticoagulation.
Dalteparin
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5
Vitamin K antagonists, such as __________, are commonly used anticoagulants.
Warfarin
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6
DOACs like Dabigatran have an advantage over Warfarin due to __________.
more predictable pharmacokinetics and less need for monitoring
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7
The function of Serotonergic antidepressants in relation to platelets is to __________.
impair platelet aggregation
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8
Thrombocytopenia is defined as a platelet count of __________.
< 150 × 10^9/L
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9
Antidotes are required prior to major surgery or in __________ situations.
overdose
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10
Fish oil is commonly used for its __________ benefits, including cardiovascular support.
anti-inflammatory
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11
Ginger should be discontinued at least __________ prior to surgery to minimize bleeding risks.
1-2 weeks
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12
A main mechanism of action for Clopidogrel is its role as a __________ receptor antagonist.
P2Y12
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13
Fondaparinux selectively inhibits __________ in the coagulation cascade.
Factor Xa
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14
The use of COX-2 selective inhibitors is often preferred to minimize __________ effects.
gastrointestinal
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15
Garlic, Ginkgo, and Ginger are examples of __________ medicines with antithrombotic effects.
complementary
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16

What are antithrombotic agents?

Medications used to prevent or treat thrombosis by inhibiting blood clot formation.

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17

Name three classes of antithrombotic agents.

Antiplatelet agents, anticoagulants, and thrombolytics.

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18

What is the primary action of thrombolytics?

To dissolve existing blood clots.

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19

Common side effects of anticoagulants include __________.

bleeding and bruising.

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20

What is the mechanism of action for antiplatelet agents?

They inhibit platelet activation and aggregation.

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21

How does Warfarin function as an anticoagulant?

By inhibiting vitamin K-dependent clotting factors.

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22

What role does Heparin play in anticoagulation?

It enhances the activity of antithrombin III, leading to increased inhibition of thrombin and factor Xa.

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23

Examples of thrombolytic agents include __________ and __________.

Alteplase and Reteplase.

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24

What is the antidote for Warfarin overdose?

Vitamin K.

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25

What is the importance of monitoring INR levels in patients on Warfarin?

To prevent bleeding complications and ensure safe therapeutic levels.

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