Failure of negative selection and peripheral tolerance of B cells

0.0(0)
studied byStudied by 0 people
learnLearn
examPractice Test
spaced repetitionSpaced Repetition
heart puzzleMatch
flashcardsFlashcards
Card Sorting

1/3

encourage image

There's no tags or description

Looks like no tags are added yet.

Study Analytics
Name
Mastery
Learn
Test
Matching
Spaced

No study sessions yet.

4 Terms

1
New cards

What happens to self-reactive B cells in the bone marrow?

They undergo receptor editing or become anergic.

2
New cards

What if receptor editing fails to fix B-cell self-reactivity?

The B cell undergoes apoptosis.

3
New cards

What protein triggers apoptosis in self-reactive B cells?

Bim triggers apoptosis in these B cells.

4
New cards

What is the result of losing Bim function?

Loss of Bim leads to failure of central tolerance and production of autoreactive B cells.