Failure of negative selection and peripheral tolerance of B cells
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4 Terms
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What happens to self-reactive B cells in the bone marrow?
They undergo receptor editing or become anergic.
2
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What if receptor editing fails to fix B-cell self-reactivity?
The B cell undergoes apoptosis.
3
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What protein triggers apoptosis in self-reactive B cells?
Bim triggers apoptosis in these B cells.
4
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What is the result of losing Bim function?
Loss of Bim leads to failure of central tolerance and production of autoreactive B cells.
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