Glucose Transporters

Glucose Transporters

proteins that facilitate the movement of glucose across cell membranes

Where are GLUT1 and GLUT3 found

GLUT1 and GLUT3 are found in almost all mammalian tissues

What are GLUT1 and GLUT3 used for

Used for basal glucose uptake (Km=1mM)

Where is GLUT2 found

In liver and pancreatic beta-cells

What is GLUT2’s Km

15-20 mM

Where is GLUT4 found

In muscle and fat cells

What is GLUT4’s Km

5mM

What stimulates the release of vesicles of pre-made GLUT4

Insulin stimulates the release of vesicles of pre-made GLUT4

What increases the amount of GLUT4 present

Endurance training increases the amount of GLUT4 present

Where is GLUT5 found

In the small intestine

What does GLUT5 transport

fructose