Potassium-Sparing Diuretics

potassium-sparing diuretics target __________ cells and __________ cells in the DCT and collecting duct.

principle, alpha-intercalated

aldosterone is released from the __________ in response to angiotensin II, _____ sodium, and ______ potassium.

zona glomerulosa, low, increased

aldosterone binds to __________ receptors inside principal cells.

intercellular

aldosterone increases expression of __________, __________ channels, and __________.

epithelial Na+ channel, K+ channels, Na+/K+ -ATPase

water follows Na+ across aquaporins into the blood in a process called __________.

faultative water absorpion

aldosterone blockers inhibit aldosterone binding to its __________ receptor.

intracellular

ENAC and Na+/K+-ATPase blockers inhibit __________ movement across principal cells.

Na+

examples of aldosterone blockers are ______ and ______.

spironolactone, eplerenone

examples of ENAC and Na+/ K+ - ATPase blockers are _______ and ______.

triamterene, amiloride