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What are the three phases of normal wound healing?
Lag or inflammatory phase (~5 days)
Repair phase (~6-18 days)
Connective tissue repair
Wound contraction
Epithelialisation
Remodelling phase
(Considerable overlap between phases)
List the local factors that effect wound healing?
Wound perfusion —> hypovolaemia, hypotension, vessel injury, pain
Tissue viability —> trauma, dehydration, osmotic injury (if high disinfectant conc.), envenomation, chemical injury
Wound fluid accumulation —> haematoma or seroma
Infection
Mechanical factors —> tension, motion, pressure
List the systemic factors that affect wound healing?
Immunosuppression
Systemic disease (FIV, hyperadrenocorticism)
Glucocorticoid administration
Neoplasia
Residual disease
Cytotoxic drugs / radiotherapy
Cachexia
What is taken into consideration in order to classify wounds?
(evaluate whole patient):
Degree of contamination
Aetiology
Location
Recall the classification of wounds in terms of degree of contamination

Abrasion definition
A partial thickness wound with loss of epidermis and part of dermis

Avulsion definition
Tearing of tissue from its attachments

De-gloving injury definition
Low-velocity avulsion of skin due to rotational forces (typically in road accidents).
Incision definition
Sharp trauma resulting in a smooth-edged wound with minimal tissue trauma.
Laceration definition
Sharp trauma resulting in an irregular wound with tearing of tissue and trauma of underlying tissue.
Puncture wound definition
Penetration by a missile or sharp object. Often minimal superficial damage with substantial damage to deeper structures
How to prepare wound for treatment?
Take swabs for bacteriology before cleaning
Prevent further contamniation by covering with sterile water soluble gel or sterile saline-soaked swabs
Begin clipping at wound edges and work away (minimises hair contamination)
Can prepare skin with but DO NOT allow surgical scrub to enter wound
Lavage

What are the aims of lavage?
Decrease the number of bacteria in the wound
Remove debris
Prevent further contamination
Prevent transformation of acute clean-contaminated or contaminated wounds into infected wounds
Convert contaminated or clean-contaminated wounds into wounds suitable for primary closure
How to carry out pressure irrigation for hydrodynamic debridement (lavage)?
Using a 20ml syringe with an 18g needle
Antiseptics can be added to the final lavage —> they must not contain detergent
How does hydromechanical debridement work?
Amorphouse hydrogel dressing (e.g. Intrasite)
Promote hydration and autolysis of necrotic tissue, absorb sloughing tissue, allow optimum cell migration and proliferation
Contain bacteriostatic propylene gel
(when first take dressing off may appear worse because gel has absorbed pus)
How does surgical debridement work?
Use aseptic technique to avoid further infection
Evaluate viability of issues based on colour, pulse and bleeding
Remove all devitalised tissue and foreign material (scalpel not scissors), preserve important structures for function unless very obviously necrotic and non viable
Lavage again after debridement
What to do if unsure about viability of tissues?
Manage as open wound for 48-72 hours until obvious demarcation of devitalised tissues occur
Immediate debridement is only essential in massive, deep or grossly necrotic wounds that may cause sepsis
After debridement how do we decide an appropriate management technique? List these techniques and what they require
Reassess and recategorise

What is open wound management?
Combines continued debridement by lavage, repeated surgical debridement or use of topical preparations and dressings and protection of the wound to provide an optimum environment for healing
How many layers are there in a dressing?
3 layers
Primary (contact) —> adherent (no longer standard of care) or non adherent
Secondary
Tertiary (outermost)
Describe a wet-to-dry bandage
Adherent primary bandage —> pulls debris off surface of wound —> delayed healing because takes surface cells away with it when taken off
What does the choice of primary layer depend on?
Desired function
For debridement you would choose nonadherent dressing with hydrogel
For protection of wound and maintenance of optimum enviroment for healing you would you simple non adherent dressing
What factors do you consider when choosing the type of non adherent primary layer?
Amount of exudate production —> prevent wound drying out but allow excess moisture to escape (preventing maceration), more exudate requires more absorbable or permeable dressing
If wound in infected require more frequent dressing changes & lavage (at least daily)
What are the classifications of non adherent dressings and what is the aim
Semi occlusive (passes moisture through) or occlusive (traps moisture underneath)
All aim to allow excess exudate to drain but to keep wound moist
List the types of non adherent dressings and their general features
Calcium alginate (seaweed) —> absorb exudate & water on contact with wound surface
Fenestrate polyester film dressing (Melolin) —> polyester film stops dressing adhering to tissue
Hydrocellular dressings (Allevyn) —> extremely absorbent but do not transmit liquids to secondary layer
Hydrocolloid dressings —> mainly composed of cellulose that absorbs moisture and exudate becomes gel
Polyethylene/polyurethane film dressings —> non-absorben but some pass water vapour into secondary layer
Petrolatum-impregnated gauze —> non absorbent and hydrophobic
Hyperosmolar agents —> honey and home-made sugar dressing which are hyperosmolar and dehydrate bacteria (must be sterile - clostridia is in untreated honey)
Maggots —> larvae of lucilia sericata —> enzymatic destruction of necrotic healing & secretions stimulate fibroblast activity
Silver dressings —> release bactericidal silver ions
When is each non adherent dressing used?
Calcium alginate —> wounds at any stage of healing with moderate to heavy exudation, removed by lavage
Fenestrate polyester film dressing (Melolin - shiny side face down) —> protecting wounds with intact epithelial surface
Hydrocellular dressings (Allevyn) —> surface wounds or cavities e.g. ulcers
Hydrocolloid dressings —> can handle wide range of exudate volumes
Polyethylene/polyurethane film dressings —> indicated for protection of wounds with an intact epithelial surface
Petrolatum-impregnated gauze —> wounds in later stages of repair because may slow epitheliasation- mainly used for protecting wounds with an intact surface but fragile epidermis
Maggots —> may be more useful as antibacterial resistance becomes more common
What are the roles of the secondary layer?
Absorbs excess fluid from wound
Secures primary layer
Obliterates dead space
Protects wound
List some types of secondary layer
Cast padding, disposable nappies, absorbent pads and cotton wool
What are the functions of the tertiary layer?
Secures rest of dressing
Keeps dressing clean and dry
Ensure not too tight
Use sufficient secondary layer
Distribute tension evenly
Estimate pressure manually
Monitor the patient after application
What is commonly used for the tertiary layer?
Gauze bandage (elastic or nonelastic) covered by surgical tape or a self-adhesive elastic bandage e.g. Vetrap