Glucose Transporters (GLUT 1-14)

GLUT 1

Tissue Expression: Almost every cell erythrocyte

GLUT 1

Function: transport of glucose across the plasma membranes of almost every cell

GLUT 2

Tissue Expression: Liver, pancreatic β-cells, hypothalamus, a basolateral membrane of the small intestine epithelium

GLUT 2

Function: Glucose absorption in intestines (on basolateral side) and reabsorption in kidneys

GLUT 3

Tissue Expression: Nerves, brain, retina, placenta, testis,

GLUT 3

Function: Transport of glucose across the plasma membranes. Specific to neurons.

GLUT 4

Tissue Expression: Adipose tissue, skeletal muscle, heart muscle.

GLUT 4

Function: Insulin mediated glucose transport

GLUT 5

Tissue Expression: Small intestine epithelial cells, sperm, kidney, adipose tissue, retina

GLUT 5

Function: Intestinal fructose absorption

GLUT 6

Tissue Expression: the lysosomal membrane in macrophages

GLUT 7

Tissue Expression: Liver, intestines

GLUT 7

Function: mediates glucose transport across the endoplasmic reticular membrane

GLUT 8

Tissue Expression: Testes, brain, adipose tissue, liver, spleen

GLUT 9

Tissue Expression: kidney, liver, placenta, colon

GLUT 9

Function: renal urate reabsorption by proximal tubules; Does not transport glucose

GLUT 10

Tissue Expression: heart, lung

GLUT 10

Tissue Expression: maintains the integrity of major arteries through regulation of redox homeostasis and mitochondrial function

GLUT 11

Tissue Expression: muscle, heart, kidney, placenta, pancreas, adipose tissue

GLUT 11

Function: found in cell junction, integral membrane, nucleus

GLUT 12

Tissue Expression: heart

GLUT 12

Function: a basal glucose transporter in the heart

GLUT 13

Function: brain

GLUT 13

Function: proton-coupled myoinositol symporter in the brain

GLUT 14

Tissue Expression: exclusively expressed in the human testis

GLUT 14

Function: similar to GLUT 3 (Transport of glucose across the plasma membranes. Specific to neurons.)