Oxidation-Regulated TFs in Humans

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7 Terms

1
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What is Nrf2?

Major ROS-protective transcription factor

2
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What inhibits Nrf2 under normal conditions?

Keap1

3
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How does Keap1 regulate Nrf2?

Cytoplasmic retention and proteasomal degradation

4
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How many cysteines does Keap1 have?

27

5
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How does H2O2 activate Nrf2?

By oxidising Keap1

6
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Is Nrf2 directly oxidised?

No

7
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What is the result of Keap1 oxidation?

Nrf2 stabilisation and gene activation