PA - 510: Fluoroquinolones KEY INFO

Fluoroquinolones: type of drug

antibiotics

Fluoroquinolones: MOA

Inhibit DNA gyrase (topoisomerase II) and topoisomerase IV

Topoisomerase II (DNA gyrase)

removes supercoiling in the DNA helix

Topoisomerase IV

affects separation of linked DNA molecules

Fluoroquinolones: Broad or Narrow Spectrum

broad spectrum

Fluoroquinolones: Bacteriocidal / Bacteriostatic

Bactericidal

Fluoroquinolones: Effective Treatment

Very effective against Gram negative bacteria and certain mycobacteria (can be used for the treatment of tuberculosis)

Fluoroquinolones: Metabolized where?

liver by cytochrome p450

Fluoroquinolones: Inhibitors of cytochrome p450

drugs broken down by cytochrome p450 may have increased serum levels

Fluoroquinolones: Side Effects

Toxic Epidermal Necrolysis & Stevens - Johnsons Syndrome

BBW: tendinitis/tendon rupture, peripheral neuropathy,and CNS effects that may occur together

Fluoroquinolones: Suffix

-floxacin

Fluoroquinolones: Categories

Second Generation

&

Third Generation

Fluoroquinolones: Second Generation Examples

ciprofloxacin (sipping) and ofloxacin (oblock)

Fluoroquinolones: Third Generation Examples

levofloxacin (levis) and moxifloxacin (mockacins)

Fluoroquinolones: Mind Map