BSCI222: Pedigrees

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7 Terms

1
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What are features of an autosomal dominant trait?

  • NEVER skips a generation

  • Every affected person has an affected parent

  • EQUALLY affects males and females

  • ~1/2 of each generation is affected

2
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What are features of an autosomal recessive trait?

  • SKIPS generations

  • EQUALLY affects males and females

  • More likely to appear among related individuals (cosanguinity)

3
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What are features of an an x-linked recessive trait?

  • Affects MORE MALES than females

  • Father DOES NOT pass to son

    • Males pass their X chromosome to all daughters but NOT their sons

4
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What are features of an x-linked dominant trait?

  • Affects MORE FEMALES than males

  • Father pass to ALL THEIR DAUGHTERS

  • Father DOES NOT pass to son

  • Affected mother passes ½ daughters and sons

5
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What are features of an an y-linked dominant trait?

  • ONLY MALES are affected

  • Passed from father to son

  • DOES NOT skip a generation

6
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What are features of an a mitochondrial trait?

  • Affected mothers pass to ALL THEIR CHILDREN

    • Only daughters can continue passing the trait

    • Trait terminates at the sons

7
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What is twin concordance?

Looking at identical twins for patterns of inheritance compared to fraternal twins

  • Greater fraction of twin pairs sharing a trait = more genetic contribution to trait