Tablet Formulation and Manufacturing Notes

Flashcards summarizing key concepts related to tablet formulation and manufacturing.

A tablet is defined as a __ prep, consisting of compressed uniform volumes of particles containing one or more API and excipient.

solid

Advantages of tablets include good patient compliance, convenience, accurate dosing, and __ stability.

chemical physical and microbial

One disadvantage of tablets is poor __, which can affect their systemic delivery effectiveness.

bioavailability

Immediate release tablets can be disintegrating, chewable, sublingual, or __.

buccal

Disintegrating tablets are meant to be __ whole.

swallowed

Effervescent tablets help in rapid drug action due to the reaction of carbonate/bicarbonate with an __.

acid

An ideal powder blend should be homogeneous, free flowing, and should cohere and adhere without __ to tablet tooling.

adhesion

A binder improves the mechanical strength of the tablet and an example is __.

PVP

Granulation improves homogeneity and prevents __ segregation.

powder

Advantages of direct compression in tablet manufacturing include reduced time and cost, and __ dissolution.

faster

Tablet coating can be used to protect the drug, mask taste, and improve __.

appearance

Tablet attributes include consistent weight, size, and appearance, along with sufficient mechanical __.

strength