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Proximate: Immediate Causation
The physiological mechanism underlying the trait of interest.
Proximate: Development
The role of developmental timeline, experience in expression of the trait of interest.
Ultimate: Adaptive Function
The role of any structural, physiological, or behavioral process that increases an individual's likelihood of surviving and reproducing compared with other conspecifics.
Ultimate: Evolution
Role of phylogeny.
1st Major Theme of Physiology
Physiological systems require integration of multiple levels of organization.
2nd Major Theme of Physiology
Organismal structure is fundamentally related to function.
3rd Major Theme of Physiology
Feedback mechanisms drive physiology.
4th Major Theme of Physiology
Gradients matter (a lot!)
5th Major Theme of Physiology
Proteins are critical mediators of physiological function.
6th Major Theme of Physiology
Physiology Changes Over Multiple Time Frames.
Different levels of Organization
atoms, molecules, cells, tissues, organs, organ systems, populations of one species, ecosystem of different species, biosphere.
Example of anatomy relating to function.
Galapagos finches and their beak sizes.
Homeostasis
Maintenance of a relatively stable internal condition.
Negative Feedback
A mechanism of response in which a stimulus initiates reactions that reduce the stimulus.
The path of negative feedback into homeostasis
Negative feedback, sensors, integrator, effectors, then back to negative feedback.
Positive Feedback
Feedback that tends to magnify a process or increase its output. Must be pushed to completion and cannot go forever. Something must break the loop.
Gradients (give an example)
Particles in a gradient move high to low in a process called diffusion. Examples can be chemical (ion, oxygen, protein, etc.) electrical, thermal, or pressure.
Darwin's 4 Postulates of Natural Selection
-Variation between individuals
-Variation is heritable
-Different variants are expected to leave different amounts of offspring
-the subset that survive the best and produce the most offspring is not random
List and explain the different case studies of natural selection we went over in class.
-Tuberculosis case study where the disease mutated to resist the antibiotic, thus becoming deadly.
-Finch case study where a rainy season resulted in more finches developing the same length of beak over time to harvest food more easily from soft seeds.
Common Misconceptions of Natural Selection
-Natural Selection does not change individuals
-Natural selection is not goal oriented
-Natural selection does not lead to perfection