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digestive system functions
ingestion, secretion, digestion (chemical and mechanical), mixing and propulsion, absorption, defecation, responsible for facilitating metabolic processes
digestive system parts
alimentary canal and accessory organs (teeth, tongue, salivary glands, liver, gallbladder, and pancreas)
alimentary canal
a ‘tube’ through the ventral body canal, approximately 30 ft long
catabolism
larger molecules are broken into smaller molecules, happens in the mouth, stomach, and duodenum, in gi tract aka digestion, can be either mechanical or chemical
anabolism
smaller molecules are used as building blocks for larger molecules, happens in the liver
mechanical digestion
includes all movements that facilitate catabolic processes, mastication, swallowing, mixing, peristalsis
purpose of mixing
increase contact of food with digestive chemicals
peristalsis
movement of muscles within the gi tract that facilitates movement of food, a progression of coordinated contractions and relaxations of the circular and longitudinal layers of the muscularis which push the bolus onward
chemical digestion
mainly accomplished by hydrolysis, fats are broken down into fatty acids and glycerol, carbohydrates are broken down from polysaccharides into monosaccharides, proteins are broken down into polypeptides and amino acids
hydrolysis
using water to break down chemical bonds
layers of the gi tract
from deep (lumen is deep) to superficial: mucosa, submucosa, muscularis, serosa/adventitia, lumen is the inside space of the tube
mucosa
a mucous membrane made of various types of epithelium sitting on the lamina propria, has various glandular cells among the epithelial cells that secrete mucous and fluid into the lumen of the tract
lamina propria
loose ct under the epithelium in mucosa, contains MALT
where is nonkeratinized stratified squamous epithelium? (mucosa)
pharynx, esophagus, anus, there for protection
where is simple columnar epithelium? (mucosa)
the stomach and intestines, there for secretion/absorption
MALT
aka mucosa associated lymphatic tissue, a prominent lymphoid tissue in the lamina propria, protects against disease
muscularis mucosae
a thin layer of smooth muscle underneath the lamina propria (still in mucosa layer), makes the tiny folds of the lining of the stomach and small intestines, increases surface area to aid digestion and absorption
submucosa
the second layer (deep) of the gastrointestinal tract, composed of loose ct that binds the mucosa to the muscularis, contains blood and lymphatic vessels (to receive absorbed substances) and the submucosal plexus
submucosal plexus
an extensive network of neurons in the submucosa
muscularis
different in the mouth, pharynx, superior and middle parts of the esophagus, and anal sphincter vs rest of the gi tract
muscularis (mouth, pharynx, superior and middle parts of esophagus, and anal sphincter)
contains skeletal muscle that allows for voluntary swallowing and control of defacation
muscularis (everywhere else)
consists of smooth muscle arranged in 2 sheets, inner circular and outer longitudinal, has the myenteric nerve plexus continuing between them
where does the muscularis layer have skeletal muscle?
mouth, pharynx, superior and middle parts of esophagus, anal sphincter
serosa
outermost later of the gi tract when its contained in the peritoneal cavity, has a slippery mesothelium surface layer, covers the intraabdominal organs as a visceral peritoneum
adventitia
outermost layer of the gi tract when its attached to surrounding tissues (ex. around the esophagus), consists of a fibrous ct arranged around the organ which it supports
peritoneum
bodys largest serous membrane, wraps around most abdominopelvic organs, the visceral peritoneum forms the serosa of the alimentary canal and covers other intraabdominal organs, it then continues around the abdominal wall as the parietal peritoneum
how does the peritoneum differ from the pericardium and pleurae?
the pericardium and pleurae smoothly cover the heart and lungs while the peritoneum has large folds that bind the organs to one another and to the cavity walls, there are 5 major folds
5 major peritoneal folds
greater omentum, falciform ligament, lesser omentum, mesentery, mesocolon
greater omentum
the largest peritoneal fold, drapes over the transverse colon and the anterior coils of the small intestine like a ‘fatty apron’, contains many lymph nodes that help combat and contain infections of the gi tract, the large amount of adipose tissue can greatly expand (as seen in people with ‘beer bellies’)
falciform ligament
attaches the liver to the anterior abdominal wall and the diaphragm
lesser omentum
suspends the stomach and duodenum from the inferior edge of the liver, forms a pathway for blood vessels (hepatic portal vein and common hepatic artery) to enter the liver, contains the common bile duct
mesentery and mesocolon
mesentery- of the small intestine, mesocolon- of the large intestine, together attach the bowel to the posterior abdominal wall, hold the intestines loosely in place as muscular contractions mix and move the luminal contents along the gi tract
retroperitoneal organs
organs that lie in the retroperitoneal space, they are covered by the peritoneum only on their anterior surfaces, ‘retroperitoneal’ only refers to the part of the organ that is actually behind the peritoneum
ex of retroperitoneal organs
kidneys, ureters, most of the pancreas, adrenal glands, aorta, inferior vena cava
phases of the digestive activities of the gi tract
3 overlapping phases, cephalic phase, gastric phase, intestinal phase
cephalic phase
the smell, sight, thought, or initial taste of food activates neural centers in the cerebral cortex, hypothalamus, and brain stem to prepare for digestion, the brain stem activates the facial and glossopharyngeal nerves to stimulate secretion of saliva, while the vagus nerves stimulate secretion of gastric juice
gastric phase
begins when food reaches the stomach, neural and hormonal mechanisms promote secretion of gastric juice and increase gastric motility
intestinal phase
begins once food enters the small intestine, neural and hormonal responses promote the continued digestion of foods that have reached the small intestine
buccal cavity
aka oral cavity, formed by the cheeks, hard and soft palates, and the tongue, mechanical and chemical digestion occurs here
mechanical digestion in buccal cavity
happens through mastication, enables food to be mixed with saliva to form a soft flexible bolus that can be easily swallowed
chemical digestion in oral cavity
saliva starts the process of chemical digestion
saliva
99.5% water with tiny amounts of dissolved ions, IgA, lysozome (a bacteriolytic enzyme), and salivary amylase (a digestive enzyme that acts on starch)
what is the only thing chemically digested in the mouth?
starch
salivary glands
secrete saliva, 3 large salivary glands secrete most of the saliva (parotid, submandibular, sublingual), smaller glands are found on the lips (labial), cheeks (buccal), palate (palatal), and tongue (lingual)
average daily salivary secretions
1-1.5 liters
salivary regulation
under control of the ans, parasympathetic stimulation promotes secretion while sympathetic stimulation decreases it, salivary centers are in the brain stem, efferent nerve impulses are transmitted by the facial and glossopharyngeal nerves, additional salivary stimulators: touch, smell, taste, and psychological factors
tongue
composed of skeletal muscle (under voluntary somatic control), forces the moistened food bolus into position for deglutition and places the bolus into contact with the teeth for chewing, extrinsic muscles of the tongue attach to bones in the area and move the tongue from side to side, intrinsic muscles originate within the tongue and alter its shape and size for speech and swallowing
dentes
aka teeth, located in sockets of the alveolar processes of the mandible and maxillae, the sockets are lined by the periodontal ligament, a typical tooth has 3 major external regions (crown, root, neck), the neck of each tooth is covered by the gingivae which extends slightly into each socket
periodontal ligament
a dense fibrous ct that anchors the teeth to the socket walls and acts as a shock absorber during chewing
gingivae
aka gums
dentin
calcified ct that forms most of the tooth, the dentin of the crown is covered by enamel, it also encloses the pulp cavity (a space filled with pulp)
enamel
a harder than bone calcified material that covers teeth
pulp (teeth)
ct containing blood vessels, nerves, and lymphatic vessels
how many dentitions do humans have? (and what are dentitions?)
2 dentitions, sets of teeth
deciduous teeth
aka baby teeth, 20 teeth which begin to erupt around 6 months of age, all are lost btwn 6-12 yrs of age
permanent teeth
aka adult teeth, 32 teeth, numbered from right to left, top (1-16) and bottom (17-32), includes molars, premolars, cuspids (aka canines), and incisors
how many molars are there?
3 on each side, top and bottom (12 total)
how many premolars are there?
2 on each side, top and bottom (aka 8 total)
how many cuspids are there?
1 on each side, top and bottom (aka 4 total)
how many incisors are there?
4 top and bottom (the 4 front teeth), (aka 8 total)
wisdom teeth
the third molars (teeth 1, 16, 17, and 32)
deglutition
swallowing food, has 3 stages, involves many muscles subject to a number of voluntary and involuntary controls
why is deglutition so complicated?
the oropharynx and laryngopharynx have respiratory functions in addition to digestive functions and swallowed food has to transit them both on the way to the esophagus and it has to do that without going into the nasal cavity or airway
3 stages of deglutition
voluntary, pharyngeal, esophageal
voluntary part of deglutition
the tongue forces the bolus to the back of the oral cavity and into the oropharynx
pharyngeal part of deglutition
begins as the bolus passes into the oropharynx, receptors send impulses to the deglutition center in the medulla and pons, returning impulses cause the soft palate to move superiorly and posteriorly to close the nasopharynx, the epiglottis moves slightly inferiorly to close the glottis
esophageal part of deglutition
begins once the bolus enters the esophagus, peristalsis pushes the bolus onward
digestive function of the esophagus
only propulsion (moving food into the stomach
esophagus
a muscular tube that begins inferior to the laryngopharynx and is positioned posterior to the trachea, leaving the neck it traverses the thoracic cavity down the posterior mediastinum before piercing the diaphragm through the esophageal hiatus
what does the mucosa of the esophagus consist of?
nonkeratinized stratified squamous epithelium
type of muscle in the muscularis in the esophagus
varies by region, superior 1/3 is skeletal muscle, inferior 1/3 is smooth muscle, intermediate 1/3 is both
upper esophageal sphincter
a sphincter at the upper end of the esophagus
lower esophageal sphincter
aka cardiac sphincter, regulates the movement of food from the esophagus into the stomach, incompetence of the les results in gerd (gastroesophageal reflux disease) which manifests as ‘heart burn’
stomach
a j shaped enlargement of the gi tract, situated between the esophagus and the first part of the small intestine, also serves as a mixing chamber and holding reservoir, the gastric muscularis has a 3rd layer of muscle (oblique muscle) to facilitate the mixing action of mechanical digestion
rugae
large folds in the mucosa of the empty stomach which enable gastric distention depending on the amount of stomach contents
size and position of the stomach
position and size changes continually as the diaphragm moves it with each breath, empty its about the size of a large sausage but its the most distensible part of the gi tract and can expand to accomodate a large quantity of food
why does the stomach also serve as a mixing chamber and holding reservoir?
because a meal can be eaten much more quickly than the intestines can digest and absorb it so the stomach helps slow the process down for the intestines
4 main regions of the stomach
cardia, fundus, body, pylorus
what type of mucosa does the stomach have?
simple columnar epithelial cells which secrete a protective mucous, columns of secretory cells extend down into the lamina propria forming gastric glands, several gastric glands open into the Botton of narrow channels called gastric pits
types of exocrine and endocrine cells in the gastric glands and pits
exocrine: mucous neck cells (produce mucous), parietal cells (produce intrinsic factor and HCl), chief cells (secrete the protease pepsinogen and gastric lipase), endocrine: g cells (located mainly in the pyloric antrum, secrete the hormone gastrin into the bloodstream)
gastric juice
formed by the secretion of the mucous, parietal, and chief cells, totals 2-3 l/day
how is the stomach protected from gastric juice?
1-3mm thick layer of alkaline mucous secreted by surface mucous cells and mucous neck cells
what does the strongly acidic nature of gastric juice do?
kills many microbes, partially denatures proteins in food, converts pepsinogen into pepsin
pepsin
the only proteolytic enzyme in the stomach
gastric lipase
splits triglycerides
intrinsic factor
aka if, needed for absorption of vitamin b12 in the terminal ileum (vitamin b12 is needed for rbc production)
gastric erosion
erosion of the stomachs epithelial lining, caused by a disturbance btwn hydrochloric acid production, pepsin secretion, and mucosal defenses, can be caused by too much alcohol consumption or use of an nsaid drug (probably too much use)
mixing waves
gentle, rippling, peristaltic movements that pass over the stomach every 15-20 sec, macerate food, mix it with secretions of the gastric glands and reduce it to chyme
chyme
a soupy liquid that is food mixed with gastric juices
does absorption occur in the stomach?
technically yes but very little bc the epithelial cells in the stomach are impermeable to most materials
timing of digestion
within 2-4 hrs after eating a meal the stomach has emptied its contents into the duodenum, foods rich in carbs spend the least time, high protein foods remain somewhat longer, emptying is slowest after a fat laden meal containing large amount of triglycerides
how does the intestinal phase begin?
at appropriate intervals, the stomach allows a small amount of chyme to pass through the pyloric sphincter and enter the duodenum to begin the intestinal phase of digestion
completion of digestion
a collective effort of pancreatic juice, bile, and intestinal juice in the small intestine
what does digestion and absorption in the small intestine depend heavily on?
secretions from the pancreas and gallbladder (liver)
pancreas
an oblong gland located posterior to the stomach in the retroperitoneal space, connected to the duodenum by the hepatopancreatic ampulla and accessory ducts, secretes enzymes (which digest food in the small intestine) and sodium bicarbonate (which buffers the acidity of chyme)
pancreatic acini
glandular clusters, about 99% of the them participate in exocrine secretion, only 1% of the clusters (pancreatic islets) form the endocrine portion of the gland
what do pancreatic islets secrete?
the hormones glucagon, insulin, somatostatin, and pancreatic polypeptide
pancreatic juice
alkaline fluid secreted into the duodenum (about 1-1.5 l/day), creates the proper ph for certain digestive enzymes in the small intestine
which digestive enzymes does pancreatic juice help and what to they do?
pancreatic amylase (digests starch), trypsin, chymotrypsin, carboxypeptidase, elastase (cleave polypeptides into dipeptides and single amino acids), pancreatic lipase (the major triglyceride digesting enzyme in adults)
liver
the bodys largest gland, second largest organ, has 2 main lobes (left and right, divided by the falciform ligament), covered by visceral peritoneum, made up of liver lobules