WBC sx and fx

What is an azurophilic granule?

a granule found in primary myelocytic WBCs that appear bluish-black

When do we first observe azurophilic granules?

promyelocyte

What is a specific neutrophilic granule?

secondary granules that appear in myelocytes, neutrophils, eosinophils, and basophils

What is housed within the neutrophil granule?

Lactoferrin, lysozymes, muramidase, collagenase

What is housed within the eosinophil granule?

mucopolysaccharides

What is housed within the basophil granule?

histamine and heparin

Which neutrophil stage(s) contain no granules whatsoever?

myeloblast

Which neutrophil stage(s) contain some granules?

promyelocyte, myelocyte, metamyelocyte

Which neutrophil stage(s) contain granules always?

segmented neutrophils

Describe the general characteristics of cellular aging (size, N:C ratio, nuclear shape, chromatin, granules, cytoplasm).

Size: large to small

N:C ratio: high to low

nuclear shape: round to irregular

chromatin: fine to coarse, no clumps to clumps

granules: none to many

cytoplasm: dark blue to light blue

Which of the neutrophil maturation stages are mitotic?

myeloblast, promyelocyte, myelocyte

Which of the neutrophil maturation stages are post-mitotic?

metamyelocyte, band, seg

Describe the general characteristics of a myeloblast (size, N:C ratio, chromatin, granules, cytoplasm).

size: large

N:C ratio: high

chromatin: fine

granules: none

cytoplasm: dark blue

Describe the general characteristics of a promyelocyte (size, N:C ratio, chromatin, granules, cytoplasm).

size: smidge larger than myeloblast

N:C ratio: high

chromatin: begin condensing

granules: azurophilic presence

cytoplasm: dark blue

Describe the general characteristics of a myelocyte (size, N:C ratio, chromatin, granules, cytoplasm).

size: still large but beginning to shrink

N:C ratio: decreasing

chromatin: condensing

granules: specific neutrohil granule presence

cytoplasm: lightening up

LAST STAGE OF DIVISION

Describe the general characteristics of a metamyelocyte (size, N:C ratio, chromatin, granules, cytoplasm).

size: getting smaller

N:C ratio: decreasing

chromatin: condensing

granules: begin to lighten up

cytoplasm: beige/pink

Nucleus: kidney bean shaped