DOSAGE FORMS AND MANUF QUIZZES

b. III only

According to USP standards, a refrigerator can be used to store pharmaceutical that specify storage in a

I. Freezer

II. Cool Place

III. Cold Place

a. I only

b. III only

c. I and II only

d. II and III only

e. I, II, and III

a. Precaution, warning, contraindications

The product inserts for any drug products contain cautionary statements. Which one of the following sequences lists the three B) types of cautions in the order of the least serious to most serious?

a. Precaution, warning, contraindications

b. Warning, contraindication, precaution

c. Warning, precaution, contraindication

d. Contraindication, warning, precaution

e. Contraindications, precautions, warning

d. II and III only

Which of the following facts concerning insulin are true?

I. Degradation occurs only in the liver

II. Product is available without prescription

III. Drug has a short plasma half-life

a. I only

b. III only

c. I and II only

d. II and III only

e. I, II, and III

c. I and II onl

Which of the following chemicals is/ are included in topical formulas as sunscreens?

I. Benzophenones

II. Cinnamates

III. Methyl salicylate

a. I only

b. III only

c. I and II only

d. II and III only

e. I, II, and III

a. I only

The Norplant Implant System is/are

I. Inserted under the skin

II. Effective for only a year

III. Classified as a targeted delivery system

a. I only

b. III only

c. I and II only

d. II and III only

e. I, II, and III

d. I, II, and III

Masking the bitter taste of drugs may be accomplished by which of the following tablet coatings

I. Enteric

II. Film

III. Sugar

a. I only

b. III only

c. II and III only

d. I, II, and III

d. Mannitol

A sweetener that is widely employed in chewable tablet formulation

a. Aspartame

b. Glucose

c. Lactose

d. Mannitol

e. Sucrose

d. II and III only

Which of the following properties is desirable in a pharmaceutical suspension?

I. Caking

II. Pseudoplastic flow

III. Thixotropy

a. I only

b. III only

c. I and II only

d. II and III only

e. I, II, and III

a. Bulb shape

Rectal clinical thermometer differ from oral thermometers in a. Bulb shape b. Stem length c. Distance between graduation marks on the stem d. Standards for accuracy e. Stem shape

e. Polyethylene glycols

Most commercial vaginal suppositories use a base of

a. Beeswax

b. Cocoa butter

c. Glycerin

d. Glycerinated gelatin

e. Polyethylene glycols

e. Thickening agents

Carbomers may be included in a topical product as

a. Antimicrobial preservative

b. Buffers

c. Penetration enhancers

d. Sweeteners

e. Thickening agents

d. II and III only

2. Which of the following ingredients may be present in a soft contact lens product to remove protein build-up?

I. Benzalkonium chloride

II. Subtilisin

III. Papain

a. I only

b. III only

c. II and III only

d. II and III only

e. I, II, and III

b. As a first order reaction

The decay of radioactive atoms occurs

a. At a constant rate

b. As a first order reaction

c. As a zero order reaction

d. As a second order reaction

e. At constant increasing rate

e. Auxiliary method

What method uses hand homogenizer to further reduce the particle size of the globules of the internal phase?

a. English method

b. Continental method

c. Bottle method

d. In situ method

e. Auxiliary method

d. Small globules of the internal phase is distributed throughout the vehicle in which it is immiscible

Which of the following is a characteristic of a stable emulsion?

a. Dispersed phase on standing tend to form aggregates of globules

b. Aggregates of globules rise to the top of the emulsion

c. Large globules fall to the bottom of the emulsion to form concentrated layer of internal phase

d. Small globules of the internal phase is distributed throughout the vehicle in which it is immiscible

e. None of the choices

c. Inhaler

The device where the volatile drug is contained and by virtue of its high vapor pressure are carried by air current into the nasal passage to exert their effect.

a. Humidifier

b. Vaporizer

c. Inhaler

d. Nebulizer

e. All of the choices

c. Flocculation

Aggregates held together by weak interactions that are readily broken is ____.

a. Aggregation

b. Coagulation

c. Flocculation

d. Sedimentation

e. Coalescence

b. Cationic surfactant

Benzalkonium chloride is:

a. Non-ionic surfactant

b. Cationic surfactant

c. Anionic surfactant

d. Chelating agent

e. None of the choices

e. All of the choices

Preparation containing undissolved/immiscible drugs throughout a vehicle

a. Aerosol

b. Gel

c. Magma

d. Suspension

e. All of the choices

e. All of these

Which of the following will render an aerosol effective?

a. Amount of propellant

b. Valve assembly

c. Container

d. Particle size

e. All of these

c. Bacteriostatic Water for Injection USP

Which is "Not intended for Neonates"?

a. Water for Injection USP

b. Sodium Chloride Injection USP

c. Bacteriostatic Water for Injection USP

d. Sterile Water for Injection USP

e. All of these

a. Steam sterilization

Microbial destruction is caused by denaturation and coagulation of bacterial proteins by moist heat.

a. Steam sterilization

b. Gas sterilization

c. Ionizing radiation

d. Bacterial filtration

e. Dry heat sterilization

a. Regular insulin injection

This is the only insulin preparation administered intravenously as an emergency procedure?

a. Regular insulin injection

b. Insulin infusion pump

c. Insulin zinc suspension

d. Lispro insulin solution

e. Isophane suspension

d. SC

4. The usual route for insulin preparation

a. IM

b. IV

c. ID

d. SC

e. None of these

e. I, II, and III

Purified Water USP is obtained by this process.

I. Distillation

II. Ion Exchange Method

III. Reverse Osmosis

a. I only

b. II only

c. III only

d. I and III

e. I, II, and III

d. I and III

Process used in purifying Water for Injection USP.

I. Distillation

II. Ion Exchange Method III. Reverse Osmosis

a. I only

b. II only

c. III only

d. I and III

e. I, II, and III

c. Bacillus stearothermophilus

The biological indicator/s for steam distillation:

a. Bacillus subtilis

b. Bacillus pumilus

c. Bacillus stearothermophilus

d. All of these

e. B. subtilis and B. pumilus

d. All of these

Biological indicator/s for ionizing radiation

a. Bacillus subtilis

b. Bacillus pumilus

c. Bacillus stearothermophilus

d. All of these

e. None of these

b. [Drug] for injection

Which type of injections is a dry powder intended for reconstitution with the proper vehicle?

a. [Drug] injection

b. [Drug] for injection

c. [Drug] injectable suspension

d. [Drug] injectable emulsion

e. All of these

d. In situ method

The emulsifier in this method is the product of reaction between the vegetable of higher fatty acid & lime water

a. English method

b. Bottle method

c. Continental method

d. In situ method

e. Auxiliary method

b. Continental method

The method where the emulsifying agent is triturated in a mortar with the oil then water is added.

a. English method

b. Continental method

c. Bottle method

d. In situ method

e. Auxiliary method

e. Highly polar material which is hydrophilic and forms stable o/w emulsion

Tween 80 has an HLB value of 15. Which best describes the material and emulsion produced?

a. Highly polar material which is hydrophilic and forms stable w/o emulsion.

b. Less polar material which is hydrophobic and forms stable w/o emulsion. c. Highly polar material which is hydrophobic and forms o/w emulsion

d. Less polar material which is hydrophilic and forms a stable w/o emulsion.

e. Highly polar material which is hydrophilic and forms stable o/w emulsion

d. It is desirable feature that the density of the vehicle is lighter than that of the suspensoid.

Which is true for suspension?

a. The more viscous the suspension, the easier it will redisperse the suspensoid.

b. The rate of sedimentation is increased with increasing viscosity.

c. If the density of suspension is lesser than that of the vehicle, the faster the sedimentation rate.

d. It is desirable feature that the density of the vehicle is lighter than that of the suspensoid.

e. All of the choices

b. Vaporizer

This produces a fine mist of steam used to humidify a room

a. Humidifier

b. Vaporizer

c. Inhaler

d. Nebulizer

e. All of the choices

e. None of the choices

The following are examples of lyophobic colloids EXCEPT:

a. Emulsions

b. Suspensions

c. Foams

d. Aerosols

e. None of the choices

e. Coalescence

This is an irreversible process where dispersed globules that have flocculated and/or creamed can fuse together, resulting in larger globules.

a. Aggregation

b. Coagulation

c. Flocculation

d. Sedimentation

e. Coalescence

b. Coalescence

The instability of emulsion can be classified as:

a. Creaming

b. Coalescence

c. Phase inversion

d. Miscellaneous physical/chemical changes e. All of the choices

c. I and III

Which of the following have liquid as continuous phase?

I. Emulsion

II. Aerosols

III. Suspensions

a. I, II, and III

b. II and III

c. I and III

d. Only I

e. Only III

c. Housing

Which is not a component of an aerosol formulation?

a. Product concentrate

b. Propellant

c. Housing

d. Active ingredient

e. None of the choices

d. Suspension

Example/s of a coarse dispersion

a. Aerosol

b. Gel

c. Magma

d. Suspension

e. All of the choices

a. Aerosol

Which is a colloidal dispersion of a gas in liquid?

a. Aerosol

b. Gel

c. Magma

d. Suspension

e. All of the choices

c. 7 to 14 days

What is the expiration date for dry powders for reconstitution after filling with a suitable solvent?

a. 24 hours

b. 3 days

c. 7 to 14 days

d. 21 days

e. None of these

b. Colorant

Which of the following components is never used as an additive in preparing parenteral products?

a. Buffer

b. Colorant

c. Stabilizer

d. Antibacterial

e. Antioxidant

A. I only

Which of the following test requirements is/are done to avoid distribution and use of parenterals that contain particulate matter?

I. Clarity

II. Sterility

III. Pyrogen

A. I only

B. II only

C. III only

D. Both I and II

E. I, II and III

B. Sodium Chloride Injection USP

Which is used as catheter or IV lines to infuse fluids & medications?

A. Water for Injection USP

B. Sodium Chloride Injection USP

C. Bacteriostatic Water for Injection USP

D. Sterile Water for Injection USP

E. All of these

D. Bacterial Filtration

What is the method of sterilization best suited for extemporaneous preparation of sterile solution?

A. Steam sterilization

B. Gas sterilization

C. Ionizing radiation

D. Bacterial Filtration

E. Dry heat sterilization

E. Dry heat sterilization

Fixed oils, glycerin, petrolatum and paraffin can be sterilized using this:

A. Steam sterilization

B. Gas sterilization

C. Ionizing radiation

D. Bacterial Filtration

E. Dry heat sterilization

E. Isophane Insulin suspension

Protamine is added to this insulin preparation:

A. Regular insulin injection

B. Insulin infusion pump

C. Insulin Zinc suspension

D. Lispro insulin solution

E. Isophane Insulin suspension

D. Lispro insulin solution

Identify the short acting zinc insulin prepared by reversing the amino acids at the 28 and 29 insulin chain.

A. Regular insulin injection

B. Insulin infusion pump

C. Insulin Zinc suspension

D. Lispro insulin solution

E. Isophane Insulin suspension

C. Gamma radiation

Which one of the following forms of radiation has the greatest penetrating power?

A. Alpha radiation

B. Beta radiation

C. Gamma radiation

D. X-rays

C. I and II only

Which of the following descriptions is/are correct concerning the sterilization by membrane filtration of an extemporaneously prepared solution?

I. Suitable for heat labile drug solutions

II. Convenient for sterilizing small volumes

III. Greater assurance of sterility than using autoclaving

A. I only

B. III only

C. I and II only

D. II and III only

A. Acanthamoeba

A second microorganism that has resulted in ophthalmic infections in patients using contact lens solutions is

A. Acanthamoeba

B. Aspergillus

C. Escherichia

D. Helicobacter

A. Lactose

Which one of the following diluents is usually used for compressed vaginal tablet formulation?

A. Lactose

B. Starch

C. Sucrose

D. Talc

D. The release and absorption of drugs is predictable

Characteristics of rectal drug administration include all of the following EXCEPT:

A. Neutral pH of colon fluids lessens possible drug inactivation by stomach acidity

B. Drugs may avoid first-pass effect hepatic inactivation

C. Drugs intended for systemic activity can be administered

D. The release and absorption of drugs is predictable

C. I and II only

The FRENCH scale is commonly used in this country for denoting the diameters of

I. Urinary catheters

II. Enteral feeding tubes

III. Syringe needles

A. I only

B. III only

C. I and II only

D. I, II and III

A. Erythema, pain, no blistering

Burns are classified according to relative severity. Characteristics of a first degree burn are:

A. Erythema, pain, no blistering

B. Erythema, pain, blistering

C. Blisters, pain, skin will regenerat

D. No blisters, leathery appearance of skin, skin grafting necessary

B. I and II only

Characteristics of inhalation aerosol dosage form include

I. Avoid first pass effect

II. Rapid onset of action

III. Can administer large amounts of drug to intended use

A. I only

B. I and II only

C. II and III only

D. I, II and III

A. Antimicrobial preservative

Benzyl alcohol is present in some parenteral solutions as

A. Antimicrobial preservative

B. Anti-oxidant

C. Chelating agent

D. Tonicity adjuster

B. Bulking agent

Mannitol may be included in lyophilized products as

A. Buffer

B. Bulking agent

C. Preservative

D. Sweeteners

D. Tablets should be administered with milk to avoid gastric irritation

Which of the following statement/s concerning bisacodyl is NOT TRUE?

A. Laxative action occurs within 6 hours after oral administration

B. Suppositories may cause rectal irritation with continued administration

C. Tablets should be swallowed whole

D. Tablets should be administered with milk to avoid gastric irritation

C. mL of solvent required to dissolve 1 g of solute

Solubility of a substance may be expressed in several ways. When a quantitative statement of solubility is given in the USP, it is generally expressed as

A. Gram of solute in 1 mL of solvent

B. Gram of solute soluble in 100 mL of solvent

C. mL of solvent required to dissolve 1 g of solute

D. mL of solvent required to dissolve 100 g of solute

B. III only

A pharmacist has reconstituted a powder dosage form to form a solution. Which of the following statement/s concerning a Beyond-Use-Fate is/are appropriate when determining an expiration date for this product?

I. The beyond use date is identical to the manufacturer's expiration date

II. The beyond use date is never more than 10 days for reconstituted products

III. The beyond use date for non-solid dosage form shall not be greater than one year from the date of dispensing

A. I only

B. III only

C. I and II only

D. II and III only

D. Both statements are incorrect

Microemulsions are thermodynamically stable, optically transparent isotropic mixtures of biphasic w/o system stabilized with surfactants. Wet gum method is also known as Continental method.

A. 1st statement is correct; and 2nd statement is incorrect

B. 1st statement is incorrect; and 2nd statement is correct

C. Both statements are correct

D. Both statements are incorrect

A. Insulin Glulisine (Apidra)

The ultrashort acting insulin using recombinant DNA of Saccharomyces cervisiae (Baker's yeast) as production organism where amino acid proline is substituted in B28 position:

A. Insulin Glulisine (Apidra) B. Insulin Aspart

C. Insulin Glargine

D. Insulin Glusine and Insulin Glargine

f. None of these

Example of oral solutions, except

a. Syrups

b. Elixirs

c. Spirits

d. Tinctures

e. All of these

f. None of these

c. 95% ethanol

Alcohol USP

a. Ethyl alcohol

b. Isopropyl alcohol

c. 95% ethanol

d. tinctures

d. 70% rubbing alcohol

e. Isopropyl rubbing alcohol

d. 49%-50%

Concentration of diluted Alcohol NF

a. 95%

b.80%

c. 70%

d. 49%

e. None of these

c. Glycerin USP

Clear syrupy liquid with a sweet taste

a. Alcohol USP

b. Diluted Alcohol NF

c. Glycerin USP

d. Purified water USP

e. None of these

d. All of these

Purified Water USP, is obtained by

a. Distillation

b. Diluted Alcohol NF

c. Glycerin USP

d. All of these

e. None of these

b. % V/W

Common method/s of expressing the strengths of pharmaceutical preparations, EXCEPT

a. %W/W

b. % V/W

c. ratio of strength to weight in weight

d. % V/V

e. ratio of strength to weight in volume

f. None of these

d. Molecular diffusion

Primary mechanism responsible for mixing at the molecular level

a. Bulk transport

b. Turbulent mixing

c. Laminar mixing

d. Molecular diffusion

e. None of these

b. Magnesium Citrate oral solution

Colorless to slightly yellow clear effervescent liquid having a sweet,aciduculous taste and lemon flavor

a. Calcium hydroxide tropical solution

b. Magnesium Citrate oral solution

c. Lemon syrup

d. Guaifenesin Elixir

e. None of these

c. 85% w/v

Ideal concentration of syrup

a. 60% w/v

b. 100% w/w

c. 85% w/v

d. 50% w/w

e. none of these

b. Syrup

Concentrated aqueous preparations of sugar or sugar substitute with or without flavoring agents and medicinal substances

a. Solutions

b. Syrup

c. Elixir

d. Tinctures

e. None of these

f. None of these

Method/s of preparations for Syrups, EXCEPT

a. Solution with the aid of heat

b. Solution by agitation without the aid of heat

c. Percolation

d. Addition of sucrose to a medicated liquid or flavored liquid

e. All o these

f. None of these

c. Elixirs

Clear, sweetened hydro alcoholic solutions intended for oral use and are usually flavored to enhance palatability

a. Solutions

b.Syrups

c. Elixirs

d. Tinctures

e None of these

c. Simple solution

Method/s of preparation for Elixirs

a.Solutions with agitation

b. Solutions with the aid of heat

c. Simple solution

d. Percolation

e. All of these

f. None of these

d. Tinctures

Alocoholic or hydroalcoholic solutions prepared from vegetable materials or from chemical substances

a. Solutions

b.Syrups

c. Elixirs

d. Tinctures

e None of these

b. Sprays

Aqueous or oleaginous solutions in the form of coarse droplets or as finely divided solids to be applied to the nasopharyngeal tract

a. Inhalants

b. Sprays

c. Inhalers

d. All of these

e. None of these

a. Aluminum acetate topical solution

Colorless, faint acetous odor, sweetish, astringent taste

a. Aluminum acetate topical solution

b. Aluminum sub acetate topical solution

c. Calcium Hydroxide topical solution

d. Magnesium Citrate oral solution

e. None of these

b. Calcium Hydroxide topical solution

Official name of Lime water

a. Calcium Oxide topical solution

b. Calcium Hydroxide topical solution

c. Aluminum acetate topical solution

d. Aluminum Sub acetate topical solution

e. None of these

a. Astringent

Use/s of liquor calcis

a. Astringent

b. Laxative

c. Cathartics

d. Sweetening agents

e. None of these

c. Hydrogen peroxide topical solution

Clear, colorless liquid with an odor of ozone

a. Iodine tincture

b. Calcium hydroxide topical solution

c. Hydrogen peroxide topical solution

d. Thiomerosal topical solution

e. None of these

e. retention and excretion

Example of enemas

a. Retention

b. Evacuation

c. Excretion

d. retention and evacuation

e. retention and excretion

f. evacuation and excretion

g. All of these

h. None of these

a. Diluted acids

Aqueous solutions prepared by diluting the corresponding concentrated acids with purified water

a. Diluted acids

b. Diluted bases

c. Water

d. Diluted alcohol

e. None of these

a. Spirit

Clear, aqueous solutions saturated with volatile oil or substances

a. Spirit

b. Tincture

c. Aromatic waters

d. Liniments

e. None of these

d. Collodions

Liquid preparations composed of pyroxylin dissolved in a solvent mixture usually composed of alcohol and ther with or without a medicinal substances

a. Liniments

b. Enemas

c. Spirits

d. Collodions

e. None of these

d. All of these

Other name of Pyroxylin

a. Nitrocellulose

b. Colloidion cotton

c. Soluble gun cotton

d. All of these

e. None of these

b. Nitric acid and sulfuric acid

Pyroxylin is obtained by the action of a mixture of ___ on cotton, consists chiefly of cellulose tetranitrate

a. Nitric acid and hydrochloric acid

b. Nitric acid and sulfuric acid

c. Sulfuric acid and hydrochloric acid

d. Sulfuric acid and acetic acid

e. None of these

c. Flexible colloidons

prepared by adding 2% camphor an 3% castor oil to colloidion

a. Salicylic acid collodions

b. Waterproof colloidions

c. Flexible colloidons

d. Alcoholic colloidions

e. None of these

b. Keratolytic effect

Use/s of Salicylic Acid Collodions

a. Waterproof effect

b. Keratolytic effect

c. Antibacterial effect

d. germicidal effect

e. None of these

c. Fluidextracts

Also known as 100% tincture

a. Extractive

b. Extracts

c. Fluidextracts

d. Tincture

e. None of these

e. None of these

Form/s of extracts, EXCEPT

a. Semi-liquid

b. Powder

c. Pilular

d. All of these

e. None of these

b. Extracts

Concentrated preparations of vegetable or animal drugs obtained by removal of the active constituents of the respective drugs with suitable menstrua.

a. Fluidextracts

b. Extracts

c. Extractives

d. All of thse

e. None of these

e. Percolation

Fluidextracts are liquid preparations of vegetable drugs prepared by ______

a. Maceration

b. Decoction

c. Digestion

d. Infusion

e. Percolation

c.Prolong contact time between the drug and the affected area

Advantages of ointment

a.Chemically less stable than liquid dosage form

b.Easier handling than bulky solid dosage form

c.Prolong contact time between the drug and the affected area

d.All of these

d. All of these

Disadvantage of ointment

a.Bulkier than solid dosage forms

b.Less stable than solid dosage forms

c.When application of an exact quantity of ointment to the affected area is required, it is difficult to determine the same

d. All of these

Examples of Oleaginous base except

a.Petrolatum

b.Cetyl alcohol

c.Lanolin

d.Isopropyl palmitate

d. All of these

Characteristics of water-soluble bases

a. Anhydrous

b. Water washable

c. Absorb water to the point of solubility

d. All of these

c.Both mechanical incorporation and fusion methods

Method of preparation - ointment

a. Mechanical incorporation

b. Fusion method

c. Both mechanical incorporation and fusion methods

d. None of these