Psychedelics as Therapy

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9 Terms

1
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Psilocybin Neurotransmitters Affected

  • 5HT2A agonist

    • 5HT2A receptors densely locked in high-level association regions of brain (ex. can connect experiences together)

  • Glutamate alterations

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How does Psilocybin work in the brain?

Activate 5HT2 receptors, differences in glutamate in different regions result in ego dissolution states

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Psilocybin Indication

Depression

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MDMA (Methyldioxy-methamphetamine) Neurotransmitters Affected

  • Serotonin release at 5HT receptor

  • Dopamine agonism + NE activation (recall “m” is for methamphetamine)

5
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How does MDMA work in the brain?

Decrease amygdala activation (fear), increase resting connectivity b/w amygdala and hippocampus

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MDMA Indication

Phase 3 trial of MDMA for PTSD (not approved by FDA)

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Ketamine Neurotransmitters Affected

  • NDMA receptor antagonist (glutamate attaches here)

    • Leads to increased glutamate in other regions of the brain

  • Also LOTS of other receptors

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How does Ketamine work in the brain?

Increase glutamate in brain regions leading to body separation, altered states of consciousness

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Ketamine Indications

  • Studied for effects on PTSD

  • Approved for tx resistant depression