Antidepressants

Which drugs are considered SSRIs

Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline

which drugs are considered SNRIs

Desvenlafaxine, Duloxetine, Levomilnacipran, Venlafaxine

What are some side effects of SNRIs

Cardiovascular side effects: increased blood pressure, tachycardia, orthostatic hypertension and neuropathy

what is a contraindication of SSRIs and SNRIs

contraindicated with MAOIs (phenelzine, tranylcypromine, isocarboxazid, selegiine)

MOA of bupropion

norepinephrine and dopamine reuptake inhibitor MOA

MOA of mirtazapine

Alpha-2 antagonist (increases serotonin and norepinephrine release)

MOA of trazodone

SARI serotonin antagonist and reuptake inhibitor

MOA of vilazodone

serotonin reuptake inhibitor and 5HT-1A partial agonist

MOA of vortioxetine

seratonin reuptake inhibition, 5HT-1A agonist 5HT-3,7 and 1D antagonist

Secondary Amine tricyclic antidepressants

Despramine, Nortriptyline, Protriptyline (greater affinity for norepinephrine)

Tertiary Amine tricyclic antidepressants

amitriptyline, clomipramine, imipramine (greater affinity for serotonin)

MOA of tricyclic antidepressants

serotonin and norepinephrine reuptake inhibitor but also blocks Histamine-1 receptors, Alpha-1 receptors, Muscarinic receptors

MOA of MAOIs

Irreversibly inhibitors the enzyme MAO-A and MAO-B and these enzymes are responsible for breaking down serotonin, norepinephrine, dopamine and trace Amines

MAOI drugs

phenelzine, tranylcypromine, isocarboxazid, selegiline transdermal