5 Stages of Inflammation

What are the stages of inflammation?

1. injury/wound/insult
2. vasoconstriction
3. vasodilation
4. swelling/edema
5. healing

Stage 1:
Injury/Wound/Insult

tissue is damaged

Stage 2:
Vasoconstriction

sympathetic reaction

Does wound spew blood?

only if artery was damaged

Stage 3:
Vasodilation

brings more blood to the injured site

What dilates the vessels in stage 3?

histamine and bradykinins

Stage 4:
Swelling/Edema

cells move into damaged area
- chemotaxis -> diapedesis/ leukocyte extravasion

Stage 5:
Healing

mast cells make heparin and seratonin

What is seratonin used for in would healing?

stimulates the myofibroblasts which cause constriction and form Type 3 Collagen for "early would healing"

What is Type 3 Collagen?

Vitamin C - Reticular

What forms the scar?

fibrin