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Half of TSS cases associated with ____________
menstruation
MC pathogen of TSS
s aureus
Release of exotoxins & enterotoxins causes Massive activation of cytokine production in a host with poor antibody response to the toxin(s)
TSS
S/Sx:
•Fever/ chills
•Hypotension
•erythroderma, desquamation
•abdominal pain, vomiting, diarrhea
•weakness, myalgias
•hyperemia, sclera-conjunctival hemorrhages, ulcers, petechiae, vesicles, bullae
•elevated BUN and creatinine, metabolic abnormalities, elevated LFTs
•thrombocytopenia, anemia, prolonged PT and PTT, DIC
•headache, somnolence, confusion, irritability, agitation, hallucinations
•pleural effusion, pulmonary edema
•cardiomyopathy
TSS
begins w diffuse, red, macular rash that looks like a sunburn and involves the palms and soles
TSS
Pruritic maculopapular rash & desquamation 1-3 weeks after onset of illness
TSS
TSS dx
clinical
An otherwise healthy individual with rapid onset of:
•Fever
•Rash
•Hypotension
•Multisystem organ involvement
•Relevant risk factor: recent tampon use, surgery, infection
TSS
TSS management
fluids, pressors, surgical debridement, abx
TSS abx
vanc AND clinda AND zosyn
S/Sx:
•Lower abdominal pain, bilateral, acute
•Irregular uterine bleeding
•Cervical motion, uterine, and/or adnexal tenderness of bimanual exam
•RUQ pain, pleuritic, sometimes referred to R shoulder (Fitz-Hugh Curtis Syndrome)
PID
PID abx
ceftriaxone AND doxy AND metronidazole
PID abx time frame
14d
Potentially life-threatening complication of PID
TOA
collection of pus involving the fallopian tube, ovary, and, occasionally, other adjacent pelvic organs such as bowel and bladder
TOA
agglutination of pelvic structures
tubo ovarian complex
Risk factors and clinical presentation same as PID but can present subacutely
TOA
Ruptured abscess leaks contents into abdominal cavity; more likely to present with acute abdomen and sepsis (occurs in 15% of cases)
TOA
TOA dx
us
management of TOA:
•____________ for rupture or postmenopausal women (d/t risk of concurrent GYN malignancy)
•Can try __________ alone in pre-menopausal women who are hemodynamically stable without evidence of rupture with abscess <____cm in size
surgical exploration, abx, 7
TOA abx
ceftriaxone AND doxy AND metronidazole
Rotation of the ovary on its ligamentous support causing compromised blood supply (Will cause necrosis and loss of ovarian function)
ovarian torsion
ovarian torsion is more common in the _________ ovary
right
S/Sx:
•Acute onset of moderate-to-severe pelvic pain
•Nausea and vomiting
•Low-grade fever, more common in necrosis
•Typically, in women with h/o ovarian mass
ovarian torsion
ovarian torsion management:
•________________ for pre-menopausal pts with viable, nonmalignant ovary
•________________ for non-viable ovary, malignancy, postmenopausal pts
operative detorsion, salpingo-oopherectomy
to prevent recurrence of ovarian torsion, start pt on __________ to suppress ovarian cysts
COC
Infection of upper urinary tract/kidney, ascends from lower urinary tract
pyelonephritis
MC pathogen of pyelonephritis
e coli
Increased risk of pyelonephritis in pregnancy due to ureter ___________ from growing uterus and ______________ changes
dilation, hormonal
S/Sx:
•Fever/chills
•Flank pain
•Costovertebral angle (CVA) tenderness
•Nausea and vomiting
•May or may not be accompanied by cystitis symptoms (dysuria, hematuria, etc.)
pyelonephritis
pyelonephritis dx
UA and culture
outpatient tx of non-pregnant pyelonephritis
cipro OR levo
outpatient tx of pregnant pyelonephritis
bactrim OR augmentin
inpatient tx for non-pregnant and critical pyelonephritis
imipenem or meropenem AND vanc
inpatient tx for non-pregnant and non-critical pyelonephritis
ceftriaxone OR zosyn
inpatient tx for pregnant and mild to mod pyelonephritis
ceftriaxone
inpatient tx for pregnant and severe pyelonephritis
zosyn
spontaneous abortion is up to _____wks GA
20
•Gestational sac without yolk sac or embryo
•Previously caused blighted ovum
anembryonic pregnancy
first trimester (early) pregnancy loss is up to ______w_______d GA
12, 6
fetal demise is fetus measuring at least ____wks GA without ___________ activity
10, cardiac
2 or more spontaneous losses
recurrent pregnancy loss
2nd trimester pregnancy loss is between ________w and _______w_____d
13, 19,6
stillbirth or fetal death is loss at ______wks or greater GA
20
Bleeding in early pregnancy without clear diagnosis of loss
threatened miscarriage
miscarriage:
•__________: bleeding and cramping/pain
•__________: hemorrhage and/or infection
uncomplicated, complicated
miscarriage Dx:
• __________confirmation for anyone with suscepted miscarriage to evaluate for IUP and viability
•Confirmed if previously confirmed IUP or __________ activity no longer seen
•Labs: type & screen
•Serial beta-quantitative _____________
us, cardiac, hCG
miscarriage management:
•Inquire about ______________ pregnancy loss
•Inquire about present ____________ about the process
•Inquire about patient’s comfort with passing _____________ versus having a provider remove the pregnancy.
•Inquire about patient’s comfort with minor surgeries/procedures and their concerns about ____________ control.
previous, worries, naturally, pain
expectant management of miscarriage can be used:
•<______w GA
•Pt counseled on risk of pain, fluctuations in _________ flow, duration of +/-____ days
13, blood, 14
medication management of miscarriage can be used up to _______w_____d
19, 6
meds for miscarriage
mifepristone, misoprostol
management of miscarriage over 20wks GA
delivery
MC location of ectopic pregnancy
fallopian tubes
1st trimester vaginal bleeding and/or abdominal pain typically 6-8 weeks after LMP
ectopic pregnancy
ectopic pregnancy dx
TVUS, hCG (slow rise)
preferred management of ectopic pregnancy
medical
ectopic pregnancy meds
methotrexate
medication management of ectopic pregnancy:
•_________, stable, no __________ activity, hCG <___________ mIU/mL, can comply with posttreatment follow-up
tubal, cardiac, 5000
management of ectopic pregnancy if:
•Hemodynamically unstable
•Impending or ongoing ruptured ectopic pregnancy
•Need for concurrent surgical procedure (e.g., tubal ligation)
•Contraindication to or failed methotrexate therapy
surgical
New-onset hypertension plus significant end-organ damage dysfunction- most commonly proteinuria- after 20 weeks gestation
preeclampsia
preeclampsia:
SBP over ________mmHg and/or DBP over ______mmHg on 2 occasions 4hrs apart after ______wks gestation PLUS 1 or more of the following:
-proteinuria
-platelets under 100,000
-SCr over 1.1
-LFTs over 2x ULN
-pulm edema
-headache
-visual sx
140, 90, 20
preeclampsia w severe features:
SBP over ________mmHg or DBP over ________mmHg PLUS
-sx of _____________ dysfunction
-____________ abnormality
-thrombocytopenia
-_________ function impairment
-___________ edema
160, 110, CNS, hepatic, kidney, pulm
S/Sx:
•Severe headache that does not respond to analgesics
•Visual abnormalities
•Abdominal pain (upper, retrosternal, epigastric)
•Altered mental status
•New orthopnea or dyspnea
preeclampsia
atypical preeclampsia:
•Onset <20 weeks, rare, associated with _________ pregnancy or ________
•Postpartum-- >____ days but <____ weeks after birth
molar, APS, 2, 6
preeclampsia screening
BP checks
preeclampsia prevention includes _________ 81mg between ________wks GA
aspirin, 12-16
preeclampsia management:
•≥ 37w0d– ____________
•<37w0d- ___________ management with ___________ for severe or complications
delivery, expectant, delivery
New-onset, generalizes, tonic-clonic seizures or coma in a pt with preeclampsia.
eclampsia
Eclampsia Management:
•_________ position with supplemental oxygen
•___________ for severe HTN to preduce risk of stroke
•__________ medications
•____________
lateral, antihypertensives, antiseizure, delivery
Antiseizure meds for eclampsia:
•_____________ after seizure cessation to reduce risk of recurrence
•___________ or _____________ for seizures >5 minutes
Mg, lorazepam, diazepam
HELLP syndrome
hemolysis, elevated liver enzymes, low platelets
S/Sx:
•RUQ pain
•Proteinuria
•Hypertension
•Malaise
•N/V
HELLP syndrome
management of HELLP syndrome
delivery
actual or threatened psychologic, physical, or sexual harm by a current or former partner or spouse
intimate partner violence
Risk factors for DV perpetration:
•Exposure to ___________ violence
•Unresolved ___________especially related to returning veterans
•Recent _______ loss or instability
•___________ use disorder
childhood, PTSD, job, substance
S/Sx:
•Inconsistent explanation of injuries
•Delay in seeking care or missed appointments
•Frequent ED visits
•Late prenatal care
•Inappropriate affect
•Overly attentive partners
•Reluctance to be examined
•Difficulty with daily activities
•Difficulty with ambulation
•Memory loss
•Injuries without good explanation, especially head/neck, trunk, forearms
DV
when to screen for intimate partner violence:
-___________ primary care and obgyn visits
-pts w ______________ (particularly older adults)
-pts seen in __________ and/or upon admission
-_________________ pts
-pts w chronic unexplained _______ pain or headaches
-pts w STDs
-older adults w signs of ___________
initial, injuries, ED, pregnant, abd, neglect
penetration, no matter how slight, of the vagina or anus with any body part or object, or oral penetration by a sex organ of another person, without the consent of the victim
sexual assault
The ______________ operates a National Sexual Assault Hotline (800-656-HOPE)
•Automatically routes caller to nearest sexual assault service provider
•Free, confidential services
RAINN (Rape, Abuse & Incest National Network)
____________ creates and supports comprehensive, cost-effective responses to sexual assault, intimate partner violence, dating violence, and stalking.
•Allows for sexual assault examination without requiring law enforcement involvement.
VAWA (Violence Against Women Act)
sexual assault STI prophylaxis
ceftriaxone AND doxy AND metronidazole
additional prophylaxis following sexual assault
hep B and HPV vaccine, HIV PrEP
Assessment of safety prior to discharge of SA pts:
•Follow-up within ___________
•Complete any ______________ started
•Repeat syphilis and HIV testing in _____ and _______weeks
2wks, vaccines, 12, 24
Mandatory reporting in NC applies to _________ and ___________ adults
minors, disabled