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Flashcards covering key concepts, terminology, and details related to the urinary system, including UTIs, incontinence, renal pathology, and treatments.
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Question 1: Which of the following is the most common physiological route for bacteria to reach the kidneys and cause Acute Pyelonephritis?
Hematogenous spread via the bloodstream
Ascending infection from the lower urinary tract
Lymphatic spread from adjacent organs
Direct inoculation from traumatic injury
Answer: 2. Ascending infection from the lower urinary tract
Rationale: Most cases of pyelonephritis result from bacteria (usually E. coli) migrating from the urethra to the bladder, and then ascending the ureters into the renal pelvis and parenchyma.
Question 2: Which physiological changes occur in the kidney during the acute phase of Pyelonephritis? (Select all that apply)
Renal edema
Inflammation of the renal pelvis
Formation of abscesses in the parenchyma
Scarring and atrophy of the cortex
Infiltration of white blood cells
Answer: Renal edema, Inflammation of the renal pelvis, Formation of abscesses in the parenchyma, Infiltration of white blood cells
Rationale: Acute pyelonephritis involves inflammatory cellular infiltration and swelling. Scarring and atrophy are characteristic of chronic pyelonephritis, not the initial acute stage.
Question 3: A patient presents with fever, chills, and severe flank pain. Which assessment technique should the nurse use to confirm Costovertebral Angle (CVA) tenderness?
Deep palpation of the RUQ
Percussion of the 12th rib at the back
Auscultation of the renal arteries
Assessment of rebound tenderness at McBurney’s point
Answer: 2. Percussion of the 12th rib at the back
Rationale: CVA tenderness is assessed by placing one hand over the 12th rib at the costovertebral angle and striking it with the ulnar surface of the other fist (Murphy's punch sign).
Question 4: Which clinical manifestations are considered systemic indicators of Acute Pyelonephritis? (Select all that apply)
Tachycardia
Nausea/Vomiting
Suprapubic pressure
High fever
Leukocytosis
Answer: Tachycardia, Nausea/Vomiting, High fever, Leukocytosis
Rationale: Systemic signs indicate the body is fighting an upper-organ infection. Suprapubic pressure is a localized lower UTI (cystitis) symptom, though both may coexist.
Question 5: What is the pathognomonic diagnostic finding in a urinalysis that confirms an 'upper' urinary tract infection like Pyelonephritis?
Red Blood Cell (RBC) casts
White Blood Cell (WBC) casts
Positive Nitrites
Proteinuria
Answer: 2. White Blood Cell (WBC) casts
Rationale: WBC casts are formed only in the renal tubules; their presence in urine specifically indicates that the infection/inflammation involves the kidneys.
Question 6: Which laboratory finding in a Complete Blood Count (CBC) is most indicative of an acute bacterial pyelonephritis infection?
Thrombocytopenia
Increased neutrophils with a 'shift to the left'
Decreased Hemoglobin
Elevated Eosinophils
Answer: 2. Increased neutrophils with a 'shift to the left'
Rationale: A 'shift to the left' refers to an increase in immature neutrophils (bands), signalling the bone marrow is responding to an acute, severe bacterial infection.
Question 7: A patient with Pyelonephritis is prescribed Ciprofloxacin. This medication belongs to which drug class?
Third-generation Cephalosporins
Fluoroquinolones
Aminoglycosides
Sulfonamides
Answer: 2. Fluoroquinolones
Rationale: Fluoroquinolones like Ciprofloxacin or Levofloxacin are frequently used first-line for uncomplicated pyelonephritis due to high tissue penetration.
Question 8: Which complication should the nurse prioritize monitoring for in a patient with multi-drug resistant pyelonephritis? (Select all that apply)
Urosepsis
Septic Shock
Chronic Kidney Disease (CKD)
Diabetes Mellitus
Acute Kidney Injury (AKI)
Answer: Urosepsis, Septic Shock, Chronic Kidney Disease (CKD), Acute Kidney Injury (AKI)
Rationale: Sepsis and shock are immediate life-threats, while AKI and CKD are functional impairments resulting from damage. Diabetes is a risk factor, not a complication.
Question 9: Which patient teaching point is essential regarding the use of Phenazopyridine (Pyridium) for urinary discomfort?
It will turn the urine a bright orange/red color.
It replaces the need for antibiotic therapy.
It must be taken on an empty stomach.
It should be taken for at least 14 days.
Answer: 1. It will turn the urine a bright orange/red color.
Rationale: Phenazopyridine is a urinary analgesic. Patients must be warned about the color change to prevent alarm and to realize it only masks symptoms, not cures the infection.
Question 10: To prevent recurrence of Pyelonephritis, which lifestyle instruction should the nurse include in patient education? (Select all that apply)
Wiping front-to-back
Limiting daily fluid intake to 1 Liter
Voiding immediately after sexual intercourse
Drinking 2-3 Liters of water daily
Wearing tight-fitting synthetic underwear
Answer: Wiping front-to-back, Voiding immediately after sexual intercourse, Drinking 2-3 Liters of water daily
Rationale: Hygiene and hydration minimize bacterial ascent. Tight synthetic fabrics trap moisture; cotton/loose clothing is preferred.
Question 11: How does chronic Pyelonephritis typically present on diagnostic imaging (e.g., CT or Ultrasound)?
Enlarged, edematous kidneys
Shrunken kidneys with fibrotic scarring
Bilateral renal cysts
Normal appearing renal cortex
Answer: 2. Shrunken kidneys with fibrotic scarring
Rationale: Repeated infections lead to the replacement of functional tissue with scar tissue, causing the kidneys to atrophy and lose function over time.
Question 12: Which finding should the nurse report immediately to the healthcare provider regarding a patient being treated for pyelonephritis?
Oral temperature of 100.2^{\circ}F
Blood pressure of 88/52 mmHg
Urinary frequency
Mild flank soreness
Answer: 2. Blood pressure of 88/52 mmHg
Rationale: Hypotension is a sign of systemic inflammatory response or urosepsis, requiring emergent IV fluid resuscitation and intervention.
Question 13: Physiological stasis of urine facilitates pyelonephritis. Which conditions contribute to this stasis? (Select all that apply)
Kidney stones (Nephrolithiasis)
Vesicoureteral reflux (VUR)
Benign Prostatic Hyperplasia (BPH)
Active lifestyle and exercise
Pregnancy
Answer: Kidney stones, Vesicoureteral reflux (VUR), Benign Prostatic Hyperplasia (BPH), Pregnancy
Rationale: These factors cause either physical obstruction or backward flow, allowing bacteria to multiply in stagnant urine.
Question 14: What is the primary reason that a follow-up urine culture is ordered 1 to 2 weeks after completing antibiotics for pyelonephritis?
To check the patient's glucose level
To ensure complete eradication of the pathogen
To measure renal concentration capacity
To identify the patient's blood type
Answer: 2. To ensure complete eradication of the pathogen
Rationale: Persistent 'asymptomatic' bacteria can lead to rapid recurrence or chronic infection, and must be confirmed clear via culture.
Question 15: Which medication is often given IV for hospitalized patients with severe pyelonephritis due to its broad spectrum and renal safety profile?
Ceftriaxone
Gentamicin
Nitrofurantoin
Tetracycline
Answer: 1. Ceftriaxone
Rationale: Ceftriaxone is a third-gen cephalosporin effective against many uropathogens. Gentamicin (an aminoglycoside) is effective but carries higher risks for nephrotoxicity and ototoxicity.
Question 16: Why is Nitrofurantoin (Macrobid) typically NOT recommended for the treatment of Pyelonephritis?
It causes severe kidney damage.
It does not reach therapeutic levels in the renal tissue (parenchyma).
It is only effective against viruses.
It is restricted to pregnant patients only.
Answer: 2. It does not reach therapeutic levels in the renal tissue (parenchyma).
Rationale: Nitrofurantoin is concentrated only in the lower urinary tract and bladder; it does not achieve the tissue concentrations needed to treat an infection of the kidney parenchyma.
Question 17: Which diagnostic test provides a visual assessment of the renal structures and can detect abscesses or obstructions associated with pyelonephritis? (Select all that apply)
Renal Ultrasound
CT Scan (with or without contrast)
Voiding Cystourethrogram (VCUG)
Liver Function Test (LFT)
Electrocardiogram (ECG)
Answer: Renal Ultrasound, CT Scan, Voiding Cystourethrogram (VCUG)
Rationale: Imaging is used to identify complications like abscesses or anatomical abnormalities like reflux (VCUG). LFTs and ECGs do not assess renal structure.
Question 18: A patient with pyelonephritis has a Serum Creatinine of 2.4 mg/dL (Baseline: 1.0). What does this physiologically indicate?
Dehydration causing concentrated blood
Acute Kidney Injury (AKI) resulting from inflammation
Successful antibiotic resolution
Normal physiological aging
Answer: 2. Acute Kidney Injury (AKI) resulting from inflammation
Rationale: Elevation of creatinine signifies a reduction in the glomerular filtration rate, often due to severe inflammation and edema within the nephrons during pyelonephritis.
Question 19: Which electrolyte imbalance is a high priority to monitor if a patient's pyelonephritis leads to significant renal failure?
Hypokalemia
Hyperkalemia
Hyponatremia
Hypomagnesemia
Answer: 2. Hyperkalemia
Rationale: The kidneys are responsible for excreting potassium. If kidney function drops (AKI), potassium levels rise rapidly, leading to life-threatening cardiac arrhythmias.
Question 20: When teaching a patient with pyelonephritis about nutrition, the nurse should advise avoiding which of the following? (Select all that apply)
Caffeine
Alcohol
Water
Spicy foods
Cranberry juice
Answer: Caffeine, Alcohol, Spicy foods
Rationale: These act as bladder irritants and can exacerbate the discomfort during an active urinary tract infection. Water and cranberry juice are generally encouraged.
Question 21: Which symptom in the elderly population is most indicative of pyelonephritis despite the absence of a high fever?
Increased hunger
Acute onset of confusion or delirium
Improved mobility
Clear, odorless urine
Answer: 2. Acute onset of confusion or delirium
Rationale: Older adults often present with atypical symptoms such as altered mental status or lethargy rather than the standard fever and CVA tenderness.
Question 22: Which complication of pyelonephritis presents with gas bubbles in the renal parenchyma on imaging, primarily in diabetic patients?
Chronic Glomerulonephritis
Emphysematous Pyelonephritis
Nephrotic Syndrome
Renal Calculi
Answer: 2. Emphysematous Pyelonephritis
Rationale: This is a life-threatening, necrotizing infection caused by gas-forming organisms (like E. coli) in the renal tissue, common in patients with uncontrolled diabetes.
Question 23: During the treatment of pyelonephritis, what is the goal of administering IV fluids?
To 'flush' the bacteria through the urinary system
To cause the patient to sleep better
To increase blood viscosity
To prevent the need for antibiotics
Answer: 1. To 'flush' the bacteria through the urinary system
Rationale: High fluid flow ensures that bacteria and inflammatory debris (pus) are flushed out and maintains adequate blood flow to the kidneys.
Question 24: A pregnant patient with pyelonephritis is at risk for which complication? (Select all that apply)
Preterm labor
Chronic hypertension
Sepsis
Gestational diabetes
Premature rupture of membranes (PROM)
Answer: Preterm labor, Sepsis, Premature rupture of membranes (PROM)
Rationale: Systemic infection causes an inflammatory surge that can trigger uterine contractions and lead to early delivery or sepsis.
Question 25: Which of the following is an expected physiological benefit of using Cranberry juice/supplements for urinary health?
It kills all bacteria in the kidney
It prevents bacteria from adhering to the urinary tract lining
It increases the pH of the urine to 9.0
It acts as an anticoagulant
Answer: 2. It prevents bacteria from adhering to the urinary tract lining
Rationale: Proanthocyanidins in cranberries prevent E. coli from binding to the epithelial cells, though it cannot treat an infection that is already established.
Question 26: What should the nurse include in the medication teaching for a patient starting Trimethoprim/Sulfamethoxazole (Bactrim) for Pyelonephritis?
Avoid sun exposure/wear sunscreen
Limit fluid intake
Stop the drug if you get a mild rash
Take it only once a week
Answer: 1. Avoid sun exposure/wear sunscreen
Rationale: Sulfonamides cause photosensitivity. Note: A rash should be reported immediately as it could be the start of Stevens-Johnson Syndrome.
Question 27: Which instruction is appropriate for a patient receiving outpatient treatment for mild pyelonephritis?
Bed rest for 3 weeks
Return to the clinic if vomiting prevents antibiotic intake
Decrease water intake to keep the medicine concentrated
Stop antibiotics when flank pain disappears
Answer: 2. Return to the clinic if vomiting prevents antibiotic intake
Rationale: If the patient cannot keep oral medications down, they must be admitted for IV therapy to prevent the infection from worsening.
Question 28: Vesicoureteral Reflux (VUR) is a physiological condition where:
Urine flows backward from the bladder into the ureters
The kidney drops lower into the pelvis
The urethra is blocked by a stone
The patient produces too much urine
Answer: 1. Urine flows backward from the bladder into the ureters
Rationale: This valvular failure allows infected bladder urine to reach the kidneys, frequently causing recurrent pyelonephritis.
Question 29: Which nursing intervention is a priority during the acute phase of pyelonephritis with severe pain?
Administering analgesics and applying heat to the flank
Forcing the patient to walk 2 miles
Restricting all pain medications to avoid masking symptoms
Providing a high-potassium diet
Answer: 1. Administering analgesics and applying heat to the flank
Rationale: Comfort measures are essential; heat helps relieve the muscle spasms associated with renal inflammation.
Question 30: Which medical history factor increases the risk of 'Complicated' Pyelonephritis? (Select all that apply)
Male gender
Pregnancy
Indwelling catheter use
Immunosuppression
Normal anatomy
Answer: Male gender, Pregnancy, Indwelling catheter use, Immunosuppression
Rationale: Pyelonephritis in males, pregnant patients, or those with underlying health issues/hardware is always considered 'complicated' and requires aggressive management.
Question 31: Pyuria, a common finding in pyelonephritis, is defined as the presence of:
Glucose in the urine
Pus/White blood cells in the urine
Ketones in the urine
Protein in the urine
Answer: 2. Pus/White blood cells in the urine
Rationale: The term '-pyuria' refers to the inflammatory response where WBCs are shed into the urine to fight the infection.
Question 32: In Chronic Pyelonephritis, which physiological process leads to secondary hypertension?
Destruction of the heart valves
Damage to the renal vascular system and renin-angiotensin activation
Excessive salt consumption during illness
Inflammation of the carotid arteries
Answer: 2. Damage to the renal vascular system and renin-angiotensin activation
Rationale: Chronic renal tissue damage/scarring triggers the RAAS system, which increases blood pressure to maintain glomerular pressure.
Question 33: What is the primary causative agent responsible for nearly 80\% of pyelonephritis cases?
Pseudomonas
Staphylococcus
Escherichia coli (E. coli)
Candida albicans
Answer: 3. $$Escherichia coli (E. coli)
Rationale: This Gram-negative bacterium is the most common cause of both lower and upper urinary tract infections due to its proximity in the GI tract.
Question 34: A patient asks why they must finish a 14-day course of antibiotics instead of 3 days. The nurse explains:
14 days is required to prevent deep kidney abscesses and recurrence
3 days is enough, the doctor made a mistake
Longer courses prevent the patient from getting a cold
It ensures the patient builds immunity to the bacteria
Answer: 1. 14 days is required to prevent deep kidney abscesses and recurrence
Rationale: Unlike simple cystitis (3-5 days), pyelonephritis involves deeper tissue and requires longer therapy to ensure complete eradication.
Question 35: Which urinary diagnostic result suggests a bacterial infection? (Select all that apply)
Positive Nitrites
Positive Leukocyte Esterase
Specific Gravity of 1.010
Negative Glucose
Bacteria on microscopy
Answer: Positive Nitrites, Positive Leukocyte Esterase, Bacteria on microscopy
Rationale: Nitrites indicate Gram-negative bacteria; Leukocyte esterase indicates WBC activity. Specific gravity and glucose are not primary indicators of infection.
Question 36: Physiologically, why is Pyelonephritis more common in women?
Longer ureters
Shorter urethra and closer proximity of the anus to the meatus
Larger bladder capacity
Higher systemic blood pressure
Answer: 2. Shorter urethra and closer proximity of the anus to the meatus
Rationale: Bacteria have a shorter distance to travel to reach the urinary tract and kidneys in females compared to males.
Question 37: Which of the following is a symptom of 'Urosepsis' resulting from pyelonephritis?
Bradycardia
Altered mental status and increased respiratory rate
Hypertension
Dry, warm skin
Answer: 2. Altered mental status and increased respiratory rate
Rationale: Tachypnea and confusion are early signs of poor tissue perfusion and systemic inflammatory response (SIRS) caused by urosepsis.
Question 38: What patient education is vital for a patient with recurrent pyelonephritis regarding contraceptive use?
Using spermicides increases the risk of UTI
Using condoms decreases the risk of UTI
Birth control pills cure the infection
Contraception has no relation to UTIs
Answer: 1. Using spermicides increases the risk of UTI
Rationale: Spermicidal foams and jellies can alter the normal vaginal flora, making it easier for E. coli to colonize and ascend to the kidneys.
Question 39: During IV infusion of Gentamicin for pyelonephritis, which assessment is most critical?
Daily weights and Serum Creatinine
Checking for a skin rash
Monitoring the heart rate for bradycardia
Measuring the patient's height
Answer: 1. Daily weights and Serum Creatinine
Rationale: Aminoglycosides are nephrotoxic; monitoring creatinine and urine output is essential to detect early drug-induced kidney injury.
Question 40: What is the physiological purpose of 'White Blood Cell (WBC) casts'?
They are used to transport oxygen to the kidney
They are 'molds' formed in the renal tubules consisting of inflammatory cells
They are part of the blood clotting mechanism
They represent the breakdown of old red blood cells
Answer: 2. They are 'molds' formed in the renal tubules consisting of inflammatory cells
Rationale: Because they are cast in the shape of the tubules, they prove the inflammation is happening deep within the kidney structure.
Question 41: Which instruction should the nurse provide regarding hygiene to prevent pyelonephritis? (Select all that apply)
Avoid douching
Avoid bubble baths
Wear silk or lace underwear daily
Empty the bladder as soon as the urge is felt
Drink lots of sodas and coffee
Answer: Avoid douching, Avoid bubble baths, Empty the bladder as soon as the urge is felt
Rationale: Avoiding irritants and ensuring complete/timely bladder emptying reduces the risk of bacterial colonization.
Question 42: Chronic Pyelonephritis can eventually lead to End-Stage Renal Disease (ESRD). This means the patient will likely need:
A high-protein diet
Dialysis or Kidney Transplantation
Only oral antibiotics for life
Daily exercise to fix the scars
Answer: 2. Dialysis or Kidney Transplantation
Rationale: Once enough nephrons are replaced by scar tissue, the kidneys can no longer filter blood well enough to sustain life, necessitating renal replacement therapy.
Question 43: A patient feels much better after 48 hours of IV antibiotics for pyelonephritis. What should the nurse explain?
Answer: 2. 'You still need to complete the full course to prevent the infection from returning.'
Rationale: Symptomatic improvement happens quickly, but a deep kidney infection requires full therapy to kill all bacteria in the parenchyma.
Question 44: Which diagnostic procedure involves injecting dye to visualize the ureters and renal pelvis for possible obstructions?
Answer: 2. Intravenous Pyelogram (IVP)
Rationale: An IVP uses contrast to highlight the urinary tract, identifying stones or strictures that could be causing pyelonephritis.
Question 45: What physiological finding in urine might be present if pyelonephritis is complicated by kidney stones?
Answer: 1. Hematuria (Blood in urine)
Rationale: Stones (calculi) cause trauma to the lining of the urinary tract, often leading to hematuria as they pass or cause obstruction.
Question 46: Which of the following is a symptom of Acute Pyelonephritis? (Select all that apply)
Answer: Malaise/Fatigue, Pain at the costovertebral angle, Vomiting, Dysuria
Rationale: Standard presentation includes systemic fatigue, localized back pain, GI upset, and lower urinary symptoms.
Question 47: When managing pyelonephritis, which vital sign change suggests the patient is worsening and potentially developing septic shock?
Answer: 1. BP drops, HR increases
Rationale: Systemic vasodilation leads to hypotension, and the heart compensates by beating faster (tachycardia) to maintain cardiac output.
Question 48: Which group of people should be screened for 'Asymptomatic Bacteriuria' due to the high risk of it progressing to Pyelonephritis?
Answer: 2. Pregnant women
Rationale: Asymptomatic bacteria in pregnancy have a high likelihood of ascending to the kidneys, so they are routinely screened and treated to prevent pyelonephritis/preterm labor.
Question 49: Phenazopyridine (Pyridium) treatment for pyelonephritis should be limited to how many days typically?
Answer: 1. 2 days
Rationale: Long-term use is not recommended because it can mask the persistence of symptoms or worsening of the actual infection.
Question 50: Which of the following is a physiological defense mechanism of the urinary tract against infection?
Answer: 2. Acidic pH and frequent flushing (voiding)
Rationale: Acidity inhibits bacterial growth, and regular voiding physically removes bacteria before they can ascend.
Question 51: A patient has chronic pyelonephritis and a GFR (Glomerular Filtration Rate) of 30 mL/min. This indicates:
Answer: 1. Moderate Stage 3 Chronic Kidney Disease
Rationale: GFR is the best measure of kidney function; 30 mL/min indicates significant loss of filtration capacity due to chronic damage/scarring.
Question 52: Which medication is often withheld if a pyelonephritis patient already has pre-existing Chronic Kidney Disease? (Select all that apply)
Answer: NSAIDs, Gentamicin, IV Contrast dye
Rationale: These are nephrotoxic and can cause further damage to overstressed kidneys. Acetaminophen and Ceftriaxone are generally safer alternatives.
Question 53: Pain associated with Pyelonephritis is usually felt in which area?
Answer: 2. Lower back/Flank
Rationale: The kidneys are retroperitoneal organs located in the flank area; inflammation causes pain in the upper back/sides.
Question 54: What is the significance of 'Leukocyte Esterase' on a urine dipstick?
Answer: 2. It indicates the presence of neutrophils/inflammation
Rationale: It is an enzyme released by WBCs, suggesting that the body is reacting to an infection in the urinary tract.
Question 55: Inflammation in the kidneys can lead to 'renal parenchyma' damage. What is the parenchyma?
Answer: 2. The functional tissue, including nephrons and tubules
Rationale: Damage to this tissue is why pyelonephritis can lead to permanent kidney failure (CKD).
Question 56: Which vital sign is most helpful in monitoring for sepsis in a patient with pyelonephritis? (Select all that apply)
Answer: Temperature, Heart Rate, Respiratory Rate, Blood Pressure
Rationale: These four represent the core components of SIRS (Systemic Inflammatory Response Syndrome), which precedes sepsis.
Question 57: A patient with pyelonephritis asks if they can use a heating pad. The nurse should say:
Answer: 1. 'Yes, apply it to the painful flank area for comfort.'
Rationale: Local heat is an effective non-pharmacological comfort measure for renal colic and muscle spasms.
Question 58: A patient finishes their antibiotics for pyelonephritis. Which behavior indicates successful education?
Answer: 1. They schedule their follow-up urine culture.
Rationale: Following up to ensure 'test of cure' is vital to prevent silent chronic progression.
Question 59: Which condition causes 'physiologic' obstruction in the ureter during pregnancy, increasing pyelonephritis risk?
Answer: 1. Direct compression by the enlarging uterus and progesterone-induced relaxation
Rationale: The physical size of the uterus and hormonal changes slow down urine movement, allowing bacteria to ascend and stay in the ureters longer.
Question 60: Which statement by the nurse correctly summarizes Pyelonephritis to a patient?
Answer: 2. 'It is a serious infection of your kidney tissue that requires proper treatment to prevent damage.'
Rationale: Emphasizing the seriousness (kidney tissue) and the need for treatment (prevention of damage)