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Sensitization steps 1
Antigen-presenting cell (APC) phagocytizes and processes antigen
Sensitization steps 2
APC presents antigen determinant to TH2 cell
Sensitization steps 3
IL-4 from TH2 cell stimulates B cell
Sensitization steps 4
B cell becomes plasma cell, which secretes IgE
Sensitization steps 5
IgE binds to mast cells, basophils, and eosinophils