Sensitization steps

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Sensitization steps 1

Antigen-presenting cell (APC) phagocytizes and processes antigen

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Sensitization steps 2

APC presents antigen determinant to TH2 cell

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Sensitization steps 3

IL-4 from TH2 cell stimulates B cell

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Sensitization steps 4

B cell becomes plasma cell, which secretes IgE

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Sensitization steps 5

IgE binds to mast cells, basophils, and eosinophils