PL2003 Medicine - Capsules Manufacturing

These flashcards cover key vocabulary and concepts related to the design and manufacture of capsules in pharmacology.

HGCs

Hard Gelatin Capsules used for filling powdered drug substances.

Excipients

Substances added to drug formulations to aid processing, stability, and drug release.

Tapped Bulk Density

The mass of a powder divided by the volume it occupies after being tapped.

SGC

Soft Gelatin Capsules which are used for encapsulating liquids and semi-solids.

Bioavailability

The degree and rate at which an active pharmaceutical ingredient or active moiety is absorbed and becomes available at the site of action.

Wetting Agents

Substances that promote the penetration of fluids into powder plugs.

Granulating Agents

Substances used to form granules for easier processing in tablet formulations.

Dosator Type

A method for filling capsules that uses a specific dosing mechanism to ensure accurate fill weights.

Disintegrants

Excipients that facilitate the breakdown of tablets or capsules in the gastrointestinal tract.

Formulation Factors

Characteristics that influence the drug release and efficacy of a capsule formulation.