Final Exam Review - Treatment/Control of Parasitic infectons in Dogs and Cats

What species does Pyrantel treat?

Ancylostoma, Toxocara - broad spectrum activity for nematode parasites in GI

What is the MOA of Pyrantel?

a. Nicotine-like effect on acetylcholine receptors - spastic paralysis on parasite

b. Irreversible disturbance of neuromuscular system of nematode parasite (cant feed or stay in place)

MOA of Fenbendazole?

preferentially binds to Beta-tubulin moelcules of nematodes

what does Fenbendazole affect at the cellular level?

a. disrupts microtubular function

b. affects cell division, maintenance of cell shape, nutrient absorption, intracellular transport

c. energy deprivation so parasites starve and die

Suppressive treatment?

puppies dewormed at 2, 4, 6, 8, weeks of age (deworming at intervals shorter than ERP

Prophylactic treatment of dogs without clinical dz?

Heartworm drugs accomplish; Interceptor (Milbemycin), Heartgard Plus (IVM+Pyrantel), and Advantage Multi (Imidacloprid+Moxidectin)

What two drugs used for control of prenatal and perinatal Parasitic infections?

Fenbendazole and Ivermectin

Prevention through Hygiene?

a. remove feces from yard

b. Sandboxes covered when not in use

c. Wash hands following pet contact

d. clean dogs promptly when they roll