Hyperpolarizing

Name the four classes of potassium channels

Voltage-dependent

Rectifier

Metabotropic-gated

Calcium-dependent

Voltage-gated potassium channels have ___ alpha subunits, ___ transmembrane unite, and up to ___ intracellular _ subunits

4

6

4

Beta

What activates potassium efflux

Voltage-dependent conformational movement of the charged portions of alpha subunits

What inactivates voltage dependent potassium channels

4 positive ions binding to portions of beta subunits to block potassium efflux using a “ball and chain” method

Name the four types of voltage-dependent potassium channels

Ia, Id, Ik Im

Name the three types of rectifier potassium channels

Ik, anomalous rectifier Ihq, tandem pore

Name the four types of Metabotropic potassium channels

Im, I atp sensitive, I ahp, Isahp

Name the four types of calcium- dependent potassium channels

Ic Im Iahp Isahp

The rectifier channel anomalous has __ sets of alpha subunits with ___ transmembranes

4

2

The rectifier channel tandem pore has __ alpha subunits and ___ transmembrane that dimerize to yield a single protein with ___ pore domains but ___ pore

4

4

2

1

Which channel is applicable to the following:

HVA

Slow inactivating

A delayed rectifier

Enhancer: glycosylation

Blocker: Cs+

Rectifying channel: Ik

Which channel is applicable to the following:

HA

Slow inactivating

Enhancer: none

Blocker: Cs+

Rectifying channel: anomolous Ih(q)

Which channel is applicable to the following:

Leak channel

Non inactivating

Enhancer: halothare and isoflurare

Blocker: none

Rectifying channel: tandem pore

Which channel is applicable to the following:

HVA

Slow inactivating

Enhancer: glycosylation

Blocker: DTX, Cs+, TEA

VKDC: Ik

Which channel is applicable to the following:

LVA

Fast inactivating

Enhancer: retigabine

Blocker: DTX, Cs+, 4-AP

VKDC: Ia

Which channel is applicable to the following:

LVA

Medium inactivating

Enhancer: glycosylation

Blocker: DTX, Cs+

VKDC: Id

Which channel is applicable to the following:

LVA

Slow inactivating

Enhancer: retigabine

Blocker: linopridine & anything that blocks muscarinic channels

VKDC: Im

Which channel is applicable to the following:

LVA

Slow inactivating

Enhancer: retigabine

Blocker: PKC mediated phosphorylation

Metabotropic: Im

Which channel is applicable to the following:

Low (ATP)

Non inactivating

Enhancer: Ca+

Blocker: ATP something, phosphorylation

Metabotropic: I atp

Which channel is applicable to the following:

Non inactivating

Enhancer: Ca+

Blocker: phosphorylation

Metabotropic: Iahp, Isahp

Thinking to the calcium dependent channels for potassium channels, which are early (could be more than one)

A. Ic

B. Im

C. Iahp

D. Isahp

A & B

Thinking to the calcium dependent channels for potassium channels, which are late (could be more than one)

A. Ic

B. Im

C. Iahp

D. Isahp

C

Thinking to the calcium dependent channels for potassium channels, which are below dashed line (could be more than one)

A. Ic

B. Im

C. Iahp

D. Isahp

C & D