Tolerance and Regulation of Immunity
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Last updated 3:41 PM on 1/16/26
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10 Terms
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What is immunological tolerance?
Non-responsiveness to self-antigens
2
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What is AIRE?
Transcription factor allowing thymus expression of tissue-specific antigens
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What happens in AIRE deficiency?
Severe autoimmune disease
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Where does B cell tolerance mainly occur?
Bone marrow
5
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What is anergy?
Functional unresponsiveness
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How can naive T cells become anergic?
Signal 1 without signal 2
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What are immune privileged sites?
Eye, CNS, testis
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What is the role of Treg cells?
Suppress immune responses
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Which transcription factor defines Treg
FoxP3
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What syndrome results from Treg deficiency?
IPEX
Note 
Flashcards (32)