Wound Healing Sample Questions

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Which of the statement is TRUE?

a. Cells (epithelial cells) don’t differentiate while they proliferate.

b. During the epithelial wound healing process, the first extracellular

matrix protein to be synthesized is type II collagen.

c. Upon physical injury such as bleeding, macrophage is the first cell

type recruited to the injury site.

d. The mechanism to recruit neutrophils by platelets is called homing.

a. Cells (epithelial cells) don’t differentiate while they proliferate.

The following event can be seen when normal wound healing process

occurs EXCEPT;

a. epithelialization

b. fibrosis

c. resolution

d. matrix remodeling

e. production of TGF-beta

f. M2 macrophage transition

b. fibrosis

Upon injuries, the following events (1~4) would occur when the proper

inflammation phase happens. What is the normal order?

(1) To activate neutrophils

(2) To activate platelets

(3) To differentiate monocytes

(4) To re-epithelialize the wound site

a. (1), (2), (3), (4)

b. (2), (3), (4), (1)

c. (2), (3), (1), (4)

d. (2), (1), (3), (4)

d. (2), (1), (3), (4)

In normal wound healing, examples of physical injury include mastication. Those

of biological injury include cancer and trauma.

a. First sentence is true. Second sentence is true.

b. First sentence is true. Second sentence is false.

c. First sentence is false. Second sentence is true.

d. First sentence is false. Second sentence is false.

b. First sentence is true. Second sentence is false.

During the healing process when the provisional matrix is being made, the ideal

matrix is fibronectin because

a. it is a large protein, therefore difficult to be degraded by proteinases.

b. Protein translation does not take time.

c. it has a lot of molecular motifs by which fibronectin can be piled

up/connected to other molecular machineries.

d. this protein is the major extracellular protein produced by M2

macrophages.

c. it has a lot of molecular motifs by which fibronectin can be piled

up/connected to other molecular machineries.