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Alcohol
Depressant with the pleasurable effects of initial high followed by relaxation and disinhibition and the negative aftereffects of depression, memory loss, oxygen damage, impaired actions
Heroin
Depressant with the pleasurable effects of flush of euphoria relief from pain and negative aftereffects of depressed physiology and agonizing withdrawal
Caffeine
Stimulant with the pleasurable effects of increased alertness and wakefulness and negative aftereffects of depressed physiology and agonizing withdrawal
Methamphetamine
Stimulant with the pleasurable effects of euphoria, alertness, and energy and the negative aftereffects of irritability, insomnia, hypertension, and seizures
Cocaine
Stimulant with pleasurable effects of rush of euphoria and confidence and energy and negative aftereffects of cardiovascular stress, suspiciousness, depressive crash
Nicotine
Stimulant with pleasurable effects of arousal and relaxation and sense of well-being and the negative aftereffects of heart disease and cancer
Ecstasy (MDMA)
Stimulant and mild hallucinogen with the pleasurable effects of emotional elevation and disinhibition and the negative aftereffects of dehydration, overeating, depressed mood, impaired cognitive and immune functioning.
LSD
Hallucinogen with pleasurable effects of visual trip and the negative aftereffects of risk of panic
Marijuana
Mild hallucinogen with the pleasurable effects of enhanced sensation, relief of pain, distortion of time, and relaxation and the negative aftereffects of impaired learning and memory, increased risk of psychological disorders, and lung damage from smoke.