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Alcohol
Depression, memory loss, oxygen damage, impaired actions
Heroin
Flush of euphoria relief from pain
Caffeine
Increased alertness and wakefulness, depressed physiology and agonizing withdrawal
Meth
Euphoria, alertness, and energy
Cocaine
Rush of euphoria and confidence and energy; cardiovascular stress, suspiciousness, depressive crash
Ecstasy (MDMA)
Emotional elevation and disinhibition
LSD
Visual trip
Marijuana
Enhanced sensation, relief of pain, distortion of time, and relaxation; lung damage from smoke.