Lipid-Lowering Agents: Efficacy, Combinations, and Clinical Evidence

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10 Terms

1
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Ezetimibe

LDL ↓: Yes; TG ↓: No/none listed; Combo with statin: Yes; Clinical trial evidence for CV event reduction: Yes (marked *)

2
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Bile acid sequestrants

LDL ↓: Yes; TG ↓: May raise TG; Combo with statin: Yes; Clinical trial evidence for CV event reduction: Yes (marked *)

3
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Fibrate

LDL ↓: (not listed as primary); TG ↓: Yes; Combo with statin: Yes (fenofibrate preferred); Clinical trial evidence for CV event reduction: Yes (marked *)

4
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Niacin

LDL ↓: Yes; TG ↓: Yes; Combo with statin: Yes; Clinical trial evidence for CV event reduction: No asterisk on slide

5
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Omega-3 Fatty Acids

LDL ↓: May raise LDL; TG ↓: Yes; Combo with statin: Yes; Clinical trial evidence for CV event reduction: Yes (marked *)

6
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PCSK9 Inhibitors

LDL ↓: Yes; TG ↓: (not listed as primary); Combo with statin: Yes; Clinical trial evidence for CV event reduction: Yes (marked *)

7
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Bempedoic Acid

LDL ↓: Yes; TG ↓: (not listed); Combo with statin: Yes; Clinical trial evidence for CV event reduction: Yes (marked *)

8
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Inclisiran

LDL ↓: Yes; TG ↓: (not listed); Combo with statin: Yes; Clinical trial evidence for CV event reduction: No asterisk on slide

9
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Mipomersen

LDL ↓: Yes; TG ↓: (not listed); Combo with statin: Yes; Clinical trial evidence for CV event reduction: No asterisk on slide

10
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Lomitapide

LDL ↓: Yes; TG ↓: (not listed); Combo with statin: Yes; Clinical trial evidence for CV event reduction: No asterisk on slide