Discuss the 6 steps involved in the return of the nuclear import receptors (importins) in association with Ran GTPase

Discuss the 6 steps involved in the return of the nuclear import receptors (importins) in association with Ran GTPase. Part 1

Levels of Ran-GTP are high nucleus due to Ran-GEF

Discuss the 6 steps involved in the return of the nuclear import receptors (importins) in association with Ran GTPase. Part 2

Ran-GTP binds to importin with nuclear protein

Discuss the 6 steps involved in the return of the nuclear import receptors (importins) in association with Ran GTPase. Part 3

This binding displaces protein depositing it in the nucleus

Discuss the 6 steps involved in the return of the nuclear import receptors (importins) in association with Ran GTPase. Part 4

Ran-GTP and importin complex is returned to the cytosol via the nuclear pore

Discuss the 6 steps involved in the return of the nuclear import receptors (importins) in association with Ran GTPase. Part 5

Ran-GAP hydrolyzes Ran-GTP to Ran-GDP causing it to dissociate from importin

Discuss the 6 steps involved in the return of the nuclear import receptors (importins) in association with Ran GTPase. Part 6

Importin can now pick up another nuclear protein