bacteria

Diptheria

• AB toxin

• mechanism

  • AB →ADP-ribosylates EF-2

  • stops protein synthesis → cell death

  • pseudomembrnae in throat

  
  DIPTHERIA = DESTROYS PROTIEN

Botulinum

• AB toxin

• bloks Ach release at NMJ

  • causes paralysis

• triggered by iron environment

BOTOX = no movement = Botulinium

A-B toxin → blocks ACh → paralysis

pseudomonas aeruginosa PA

• CF AND burns

• Has all virulence tools

  • biofilm

  • toxin

  • flagella

  • pigments

• strong quorum sensing

Psuedomonas = full toolkit

PA+TA= has everything

legionella pneumpophila

• phagosome lysome fusion

• macrophages

legionella = legion of army inside

Listeria

• LLO → escapes phags

• ACTIN tail

  • important for transmission

Listeria= lets leave

salmonella

• lysome fusion

  • vesicle formation

Salmonella= secrete vesicles

Yersinia pestis

• fleas

• biofilm

• has

  • capsule

  • type 3 secration

  • YOPS → disable immune cells

• T3SS + YOPs → shut down immune system

Memory:

plague

Vibrio cholera

• quorum sensing controls toxin producion

• cholera toxin → increase cAMP → watery diarrhea

cholera=> watery diarrhea

Staphylococcu aureus

• AGR quorum sensing system

• cotnrols toxin producion

cavaitces

SA survies AGR

Streptococcus penumoniae

• competence = takes up DNA

• uses quorum sesning

Pneumonaie is very smart

our toxin bacteria

• Diphtheria → EF-2 blocked

• Botulinum → ACh blocked

• Vibrio → ↑ cAMP diarrhea

Are intracellular bacteria

• Legionella → blocks fusion

• Listeria → escapes + actin

• Salmonella → modifies vesicle

quoroum sensing

• Pseudomonas → strong

• Vibrio → toxin control

• S. aureus → AGR system

• S. pneumoniae → competence

weapons

• Yersinia → T3SS + YOPs

• Pseudomonas → everythin (virulece factors) PA