5.20 Microbiology of Pseudomonas, Pasteurella, Bordetella, Corynebacterium, and Mycobacterium

These flashcards cover key microbial pathogens including their characteristics, pathogenicity, epidemiology, and prevention/control measures.

Pseudomonas aeruginosa

Gram(-)
motile
capsulated
Obligate aerobic

Exotoxin A-specific exotoxin
Phospholipase C-penetrate to host cells
Pyocyanine (blue pigment)- kills host cells
Pyoverdin (yellow-green pigment)-limits growth of other bacteria

Human NMF: gut

Causes: pneumonia, urinary tract infections, and sepsis.

Pasteurella multocida

Gram(-)
non-motile
capsule
FAn

Human NMF: URT

Causes: various infections in humans and animals, including respiratory infections, cellulitis, and abscesses.

Bordetella pertussis

Gram(-)
non-motile
capsule
obligate aerobic

Human NMF: none

Causes: whooping cough and respiratory infections.

Corynebacterium diphtheriae

Gram(+)
non-motile
non-capsulated
obligate aerobic
rod-shaped

Exotoxin

Human NMF: URT

Causes: diphtheria, serious respiratory illness, and systemic complications.

Haemophilus influenzae type b (Hib)

Gram(-)
non-motile
capsule
FAn

Human NMF: URT

Causes: severe pneumonia, meningitis, and other infections.

Mycobacterium Tuberlculosis

Gram(+)
non-motile
non-capsulated
obligate aerobe
acid-fast stain
bacillus

Human NMF: none

Causes: tuberculosis, a serious respiratory disease that can spread to other parts of the body.

Exotoxin A

A cytotoxin produced by Pseudomonas aeruginosa that can kill host cells.

Diphtheria toxin (DT)

A potent exotoxin produced by Corynebacterium diphtheriae that inhibits protein synthesis in host cells.

Biofilm

A community of microorganisms where bacteria adhere to surfaces and are encased in a protective matrix, contributing to antibiotic resistance.

BCG vaccine

An attenuated vaccine against tuberculosis, derived from Mycobacterium bovis, administered once in a lifetime.