chapter 18: Pyruvate Dehydrogenase

Glucose after Glycolysis

• Pyruvate travels thru mitochondria

• Coverting Pyruvate > acetyl Coa > Tca cycle

• Acetyl Coa used for energy for Tca to creat NADH

• can’t reversibly go back easily (Irreversible)

• (-) spontaneous reaction = Highly favorable (-30)

PDH Complex:

Connects sugar break down to energy production

• Powers the cell

• For Cholesterol and fatty avoid

• Stop from pyruvate build up

3 enzymes

E1: Pyruvate dehydrogenase

E2: Dendrology transacetylase

E3: Dihydrolipoyl dehydrogenase

E1: Pyruvate dehydrogenase

Relases Co2

uses: TTP (cofactor: nonprotein helper)

• Vitamin B1

E2: Dihydrolipoyl transacetylase

Transfers acetyl group making Acetyl Coa

uses: Lipoic acid (cofactor: nonprotein helper)

E3: Dihydrolipoyl dehydrogenase

resets complex, regenerating Nadh+

uses: Fad and NAD+ (cofactor: nonprotein helper)

Bad thiamine (vitamin b1 defciency)

• If u lack B1 then the pdh complex will cease to start

Regulation

1* = Covenant modification

• Stop: Phoshorylation

• Start: Dephosphorylation

2* Allosteric regulation:

• inhibit their own formation