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What are the 3 main cell types in the olfactory epithelium?
Olfactory receptors
Supporting cells
Basal cells
What is the function of olfactory receptor neurons?
Detect odorant molecules and convert them into nerve signals
What structure on olfactory receptor neurons bind odorants?
Cilia that extend into the mucus layer
Why are basal cells important?
They are cells that replace damaged olfactory receptor neurons
What produces the mucus covering the olfactory epithelium?
Olfactory glands (Bowman’s glands)
Which cranial nerve carries signals from the olfactory epithelium to the brain?
Cranial nerve 1
What happens after an odorant binds to a receptor on olfactory cilia?
A G-Protein pathway causes depolarization of the olfactory neuron
Where do olfactory receptor neuron axons go after leaving the epithelium?
Through the cribriform plate to the olfactory bulb
Why does olfaction bypass the thalamus initially?
It has direct connection to the limbic system, links smell to emotion and memory
What 2nd messenger is used in olfactory signal transduction?
cAMP (via a g-protein coupled receptor)
Low threshold
Only a few molecules needed to detect smell
Outline the basic olfactory pathway
Olfactory nerves.
Olfactory bulbs.
Olfactory tracts.
What is gestation?
Sense of taste
What are the 3 type of papillae that contain taste buds?
Vallate, Fungiform, foliate
Does filiform papillae contain taste buds?
No
What cells make up a taste bud?
Gustatory cells
Supporting cells
Basal cells
What are the 5 taste modalities?
Sweet, salty, sour, bitter, umami.
Salty foods use what type of ion
NA+ (sodium)
Sour taste use what type of ion?
H+ ions enter H+ channels (Hydrogen)
Which taste modalities use g-protein mediated receptors?
Bitter, sweet and umami
Which cranial nerves carries taste from the anterior 2/3rd of the tounge?
CN VII(Facial nerve)
Which cranial nerve carries taste from the posterior 1/3rd of the tounge?
CN IX (glossoparyngeal nerve)
Which cranial nerve carries taste from the epiglottis?
CN X (vagus nerve)
Outline basic gustatory pathway.
Taste receptor
2. Cranial nerves (VII, IX, X)
Brainstem
Thalamus
Gustatory cortex in the cerebral cortex
What is vallate papillae
Large v-shaped row of taste buds in the back of the mouth