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vestibular system
deals with balance and spatial orientation; 3 semicircular canals, 2 otolith organs
spatial orientations
consists of linear motion, angular motion (rotation), tilt
vestibulo-ocular reflex
VOR, stabilizes visual input by counter rotating the eyes to compensate for head movement
vestibular labyrinth
non-hearing part of inner ear
problems with vestibular system
spatial disorientation, dizziness, vertigo, labyrinthitis, imbalance, blurred vision, illusory self motion
dizziness
non specific spatial disorientation
vertigo
sensation of rotating or spinning
labyrinthitis
inflammation of labyrith (vestibular organs and cochlea)
semicircular canals
sense angular acceleration (rotation)
otolith organs
utricle and saccule, sense linear acceleration and gravity (tilt)
semicircular canal roll
rotation on x-axis, maybe
semicircular canal pitch
rotation of y-axis, yes
semicircular canal yaw
rotation of z-axis, no
otolith organs translation
positive x-axis, positive y-axis, positive z-axis
mammalian vestibular system
do not respond to constant velocity, only respond to changes in velocity, gravity and acceleration share equivalent connection
semicircular canal shape
3/4 of a donut, toroid shape, filled with perilymph, 2nd smaller toroid filled with endolymph, canal swells at ampulla
ampulla
where swollen canals join vestibule
hair cells
mechanoreceptors, head motion causes a change in hair cell voltage and alters NT release,
push pull symmetry
hair cells in opposite ears respond in complementary way to each other, left ear depolarize while right ear hyper polarize
utricle
30,000 hair cells
saccule
contains 16000 hair cells
otoconin
hair cells encased in gelatinous structure that contains calcium carbonate
evolution of vestibular system
earliest vertebrate had 1 semicircular canal, soon added horizontal and anterior canals, more complex underwater movement and head/eye coordination
somatosensation
sensory signals from body (skin, joints, tissue, muscle), cutaneous sense (touch, temperature, pain)
kinesthesis
perception of position and movement of limbs in space (exclude vestibular)
proprioception
perception mediated by kinesthetic and vestibular receptors, more of a cognitive function
tactile receptors function
mechanoreceptors that respond to mechanical stimulation, pressure, vibration, movement
tactile receptors anatomy
embedded in outer layer (epidermis) and underlying layer (dermis) of skin
meissner corpuscles
fast adaptation, small receptive field, FA1
merkel cell neurite complexes
slow adaptation, small receptive field, SA1
pacinian corpuscles
fast adaptation, large receptive field, FA2
Ruffini endings
slow adaptation, large receptive field, SA2
kinesthetic receptors
mechanoreceptors in muscles, tendons, joints; play role in proprioception and what kinds of movements
muscle spindle
receptor located in muscle that senses muscle tension, in joints that react when joint is bent to extreme angle
Ian Waterman
cutaneous nerves connecting his kinesthetic receptors to brain destroyed by viral infection, lacks kinesthetic senses, dependent on vision for limb position, partial loss of proprioception is more common
thermoreceptor
signal changes in skin temperature, warmth fibers and cold fibers (can react to very hot temps), constantly regulating internal temp, respond when you make contact with object warmer/colder than skin
pain
sense dangerous objects, subjective experience made up of painful stimulus and emotional response, S1 and S2, can be modulated by gating (shot blocker device)
Miss C
insensitivity to pain, didn’t sneeze, cough, gag, or blink, died at 29 from preventable infections
nociceptors
sensory receptors that transmit info about noxious stimulation that could damage the skin
A-delta fibers
nociceptors, intermediate sized, myelinated sensory nerve fibers, transmit pain and temp signals, quick sharp pain
C-fibers
nociceptors, narrow, unmyelinated sensory nerve fibers that transmit pain and temp signal, throbbing sensation
spinothalamic pathway
information about skin temp and pain, slower, separate from other input until cortex
dorsal column medial lemniscal
DCML, signals from skin, tendons, muscles, joints, separate from other input until cortex
touch sensations represented somatotopically in cortex
primary somatosensory cortex (S1, top of central sulcus), secondary somatosensory cortex (S2, bottom of central sulcus); analogous to retinotopic mapping in vision
homunculus
maplike representation of regions of body in brain
phantom limb
sensation percieved from physically amputated limb, parts of brain listening to missing limbs not aware of altered connection, so they attribute activity to stimulation from issing limb
cognitive aspects of pain
anterior cingulate (perceived unplesantness), prefrontal cortex (pain sensitization), same area active during social rejection
gate control theory
pain receptors must be activated and neural gate in spinal cord must allow signals through to brain, gate neurons can be activated by extreme pressure and cold, transmitted by small diameter nerve fibers
endogenous opiates
chemicals released in body to block release or uptake of NT transmitting pain stimulation to brain, may be responsible for placebo effects
exogeneous substances
morphine, heroin, codeine
tactile sensitivity and acuity
two point threshold: minimum distance at which 2 stimuli are just perceptiable as separate, sensitivity to pressure, spatial acuity varies across body (fingertips, face, toes highest acuity)
haptic perception
knowledge of world from sensory receptors in skin, muscles, tendons, joings, involve active exploration ex. align childproof pill bottle arrows in the dark
lateral motion
texture
pressure
hardness
static contact
temperature
unsupported holding
weight
enclosure
global shape, volume
contour following
global shape, exact shape
‘what’ system of touch
geometric properties of objects are most important for visual recognition, materials properties of objects are crucial for haptic recognition, 2D picture are easily recognized visually, poor haptically
perceving patterns with touch
braille processed in V1
olfaction
sense of smell, most ancient modality
gustation
sense of taste
olfaction in mammals
receptor gene family is largest mammalian genome, humans can detect millions of airborne odorants
odor
translation of a chemical stimulus into a smell sensation
odorant
capable of being translated by nervous system into perception of smell
odorant qualities
volatile (readily evaporates), small, hydrophobic
methane and carbon monoxide
small and volatile, but we can’t smell them, no evolutionary pressure to detect because they occur in such low []
mercaptan
detectable quality of methane added to signal a gas leak
nose main purpose
filter, warm, humidify air
nasal cycle
primary airflow through nose alternates between nostrils
turbinates
folds in nose, direct air toward lungs, swelling makes nasal cycle, swap dominant nostril
olfactory cleft
narrow space at back of nose where air flows, main olfactory epithelium is located, mucus secretion, neurons
olfactory epithelium function
secretory mucus membrane in human nose primary function is to detect odorants inhaled from air
cribrioform plate
bony structure with many tiny holes, at eyebrow level, separates nose from brain, why you need sterile water in netipot
anosmia
total inability to smell, most often resulting from sinus infection or head trauma, more common with age, can be predictor of natural death coming
side effects of anosmia
loss of flavor perception, loss of smell, symptom of covid
olfactory epithelium anatomy
supporting cells, basal cells, olfactory sensory neurons (OSNs)
supporting cells
metabolic and physical support for OSNs
basal cells
precursor (stem) cells that become OSNs
olfactory sensory neurons
OSNs, main cell type in olfactory epithelium, located beneath mucus layer
cilia
hairlike protrusions on dendrties of OSNs, contain receptor sites for odorants, 1st structure involved in olfactory signal transduction
olfactory receptor
OR, region on cilia where odorants bind, 7 or 8 odorants needed for action potential
glomerulus
father info from OSNs, located in olfactory bulb, sends to mitral cell
olfactory nerves
most anterior cranial nerves, axons of OSN, bundle togerher after passing through cribiform plate to form nerve
feel of scent
polymodial nociceptors, mediated by trigeminal nerve (5th cranial nerve)
polymodial nociceptors
touch, pain, and temperature ex. eating hot pepper
amygdala-hippocampal complex
helps recognize smell of your location
entorhinal cortex
temporal lobe, associations with odor, sensory input from hippocampus,
primary olfactory cortex
O1, 1st place to process olfactory info, frontal lobe
secondary olfactory cortex
O2, orbitofrontal cortex, affective value (good or bad smell)
amygdala
vigilance and attention
parahippocampal gyrus
memory region
limbic system
olfactory cortex, amygdala, piriform cortex, entorhinal cortex, involved in emotion and memory, scents have strong emotions and memories