Rabies 4

Is there approved rabies vaccine for wold dog hybrid

No-some states allow extra label use

Wild animal hybrids that expose humans, pets, livestock should be considered for what

Euthanasia and rabies testing

bite exposures from bats or other terrestrial animals-risk varies with what

Species of biting animals, anatomically site of bite, wound severity

Do non-bite exposures from terrestrial animals often cause rabies?

Rarely

Human-human transmission

Rare exception through artificial methods: human acquired rabies from transplants from donors died from rabies

Routine delivery of health care to a patient with rabies is not indication for post exposure prophylaxis UNLESS

Exposure of mucous membranes or non-intact skin to potentially infectious saliva or neural tissue occurred

Petting a rabid animal and contact with blood, urine, or feces of a rabid animal-does it constitute an exposure

No-not indication for prophylaxis

Diagnosis of animals

No reliable ante-mortem test-need to detect antigen

Only DFA at post Mortem on brain detecting antigen

Diagnosis of Humans

No reliable ante-mortem test

Serology-antibodies not present early in disease

Virus isolation from saliva followed by PCR

Skin biopsy(nerves) Fluorescent antibody. Antigen positive early in clinical disease

Do human and animal vaccines cover all known viral variants

Yes

Pre-exposure prophylaxis are based on

ACIP-based on risk categorization 3

Rabies Immune Globulin

Post Exposure use in humans NOT previously vaccinated

Administration of rabies immune globulin only once at the beginning provides

Passive immunity for immediate protection

RIG  is administered how many times 

ONCE never given in same site as vaccination

For those who had PrEP do they recieve RIG

no

What is the most likely advice to give regarding Post exposure Prophylaxis for a technician who has had Rabies pre-exposure PrEP?

Wound cleansing. vaccines day 0 and 3. NO RIG