Last Bits of 480

dorsal root ganglion

Myelin increases membrane

resistance—and I think capacatance

Where is the K+ selectivity filter?

On th extracellular half of the channel pore.

How does the K+ selectivity filter do its job with K+

carbonyl groups stabilize K as it goes through

If capacitance goes down what happens to the graph and how can you explain it

Change in voltage goes up which means it changes FASTER which means a steeper slope

CSF turns over

3-4 times a day — NOT every three hours

Ion x is negatively charged and more concentrated outside of the cell. Is its nerst equilibrium positive or negative?

Positive

When the voltage gated Na channel is open...

the positively charged amino acids are on the external half of the phospholipiid bilayer facing the extracellular solution

Brain

—pH

—Protein

low pH

Low protein

Number of channels and IV plots

the more channels you have, the greater the slope of the plot, because more current can go through.

When is ATP required for transport across membrane

—When is it NOT

Required for A system

—NOT required for glucose

How do you know if channels inactivate?

Changing slope

glycine receptors are...

ionotropic

5HTP causes...

EPSPs

Glutamic acid—what does it do?

Makes GABA from glutamate.

glutamate, by the way, is made via glutaminase

Which results in abnormalities in both sensory and motor systems?

peripheral neuropathies

Equilibrium potential of AMPA

0mv

How do enkephalins and morphine decrease nociception at the spinal cord?

Presynaptic inhibition

N type calcium channel

voltage gated calcium channel that has a high threshold, opens quickly and is commonly found in CNS axon terminals

Occlusive stroke to Left anterior cerebral artery gives what?

muscle weakness and sensory loss

Silent synapses

only contain NMDA receptors

Rhombomeres in what part of the brain

hindbrain

Axons of granule cells are called ______ and synapse _______

mossy fibers, CA3

Laminin B2 chains

involved in synaptogenisis in that they cluster calcium at active zones

Neurotrophic factors—what do they do for cells

prevent apoptosis

Which would occur in a Xenopus (frog) embryo that had a dysfunctional chordin gene?

Lack of neural plate development

Parallel fibers are found where?

The molecular layer

_______ is to Ach receptors as ________ is to glycine receptors

Rapsyn, Gephrine

Blocking the function of which molecule would prevent late-phase LTP at Shaffer?

CREB-1

Mossy fibers of the cerebellum synapse on what specific cell type

granule cells